Cellular responses to stress

Stable Identifier
R-HSA-2262752
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Cellular responses to stress
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Cells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. Cells are also subject to internal molecular stresses such as production of reactive metabolic byproducts. The ability of cells and tissues to modulate molecular processes in response to such stresses is essential to the maintenance of tissue homeostasis (Kultz 2005). Specific stress-related processes annotated here are cellular response to hypoxia, cellular response to heat stress, cellular senescence, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, response of EIF2AK1 (HRI) to heme deficiency, heme signaling, cellular response to chemical stress, cellular response to starvation, and unfolded protein response.
Literature References
PubMed ID Title Journal Year
15709958 Molecular and evolutionary basis of the cellular stress response

Kültz, D

Annu. Rev. Physiol. 2005
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Event Information
Go Biological Process
cellular response to stress (0033554)
Orthologous Events
Cellular responses to stress (Bos taurus)
Cellular responses to stress (Caenorhabditis elegans)
Cellular responses to stress (Canis familiaris)
Cellular responses to stress (Danio rerio)
Cellular responses to stress (Dictyostelium discoideum)
Cellular responses to stress (Drosophila melanogaster)
Cellular responses to stress (Gallus gallus)
Cellular responses to stress (Mus musculus)
Cellular responses to stress (Plasmodium falciparum)
Cellular responses to stress (Rattus norvegicus)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular responses to stress (Sus scrofa)
Cellular responses to stress (Xenopus tropicalis)
Authored
Matthews, L  (2012-05-20)
Reviewed
Matthews, L  (2024-02-28)
D'Eustachio, P  (2012-05-20)
Created
Matthews, L  (2012-05-20)
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