STAB1:ligand is endocytosed

Stable Identifier
Reaction [omitted]
Homo sapiens
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The STAB1:ligand complex is endocytosed (Tamura et al. 2003, Kzhyshkowska et al. 2004, Li et al. 2011, Prevo et al. 2004; Kzhyshkowska et al. 2005). Endocytosis of stabilin-1 or stabilin-2 can occur independently of ligand binding, via clathrin (Hansen et al. 2005).

Literature References
PubMed ID Title Journal Year
15572036 Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding

Goerdt, S, Smedsrød, B, Nedredal, GI, Kzhyshkowska, J, Falkowski, M, Elvevold, K, Schledzewski, K, Olsen, R, Hansen, B, Johansson, S, Johansson, S, Longati, P, McCourt, P, Carlsson, F

Exp Cell Res 2005
21030611 Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins

Sørensen, KK, Oteiza, A, Smedsrød, B, Svistounov, D, Li, R, McCourt, P, Olsen, R

Am J Physiol Gastrointest Liver Physiol 2011
15345716 Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1)

Ni, J, Prevo, R, Banerji, S, Jackson, DG

J Biol Chem 2004
12473645 FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products

Tsujimoto, M, Sekiya, M, Ohashi, K, Nagai, R, Kimura, S, Tamura, Y, Yahagi, N, Tomita, S, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Osuga, J, Adachi, H

J Biol Chem 2003
16164023 Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL

Gratchev, A, Mamidi, S, Krusell, L, Goerdt, S, Kzhyshkowska, J, Brundiers, H

Immunobiology 2005
15345724 Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors

Hansen, B, Goerdt, S, Pervushina, O, Gratchev, A, Johansson, S, Kzhyshkowska, J, Tang, J, He, X, Martens, JH, Schledzewski, K, Nakayama, K, Mamidi, S

J Leukoc Biol 2004
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