STAB2:ligand is endocytosed

Stable Identifier
Reaction [omitted]
Homo sapiens
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The STAB2:ligand complex is endocytosed (Tamura et al. 2003, Li et al. 2011). Endocytosis of stabilin-1 or stabilin-2 can occur independently of ligand binding, via clathrin (Hansen et al. 2005).

Literature References
PubMed ID Title Journal Year
15572036 Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding

Goerdt, S, Smedsrød, B, Nedredal, GI, Kzhyshkowska, J, Falkowski, M, Elvevold, K, Schledzewski, K, Olsen, R, Hansen, B, Johansson, S, Johansson, S, Longati, P, McCourt, P, Carlsson, F

Exp Cell Res 2005
21030611 Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins

Sørensen, KK, Oteiza, A, Smedsrød, B, Svistounov, D, Li, R, McCourt, P, Olsen, R

Am J Physiol Gastrointest Liver Physiol 2011
12473645 FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products

Tsujimoto, M, Sekiya, M, Ohashi, K, Nagai, R, Kimura, S, Tamura, Y, Yahagi, N, Tomita, S, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Osuga, J, Adachi, H

J Biol Chem 2003
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