STAB2:ligand is endocytosed

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The STAB2:ligand complex is endocytosed (Tamura et al. 2003, Li et al. 2011). Endocytosis of stabilin-1 or stabilin-2 can occur independently of ligand binding, via clathrin (Hansen et al. 2005).

Literature References
PubMed ID Title Journal Year
21030611 Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins

Li, R, Oteiza, A, Sørensen, KK, McCourt, P, Olsen, R, Smedsrød, B, Svistounov, D

Am J Physiol Gastrointest Liver Physiol 2011
15572036 Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding

Hansen, B, Longati, P, Elvevold, K, Nedredal, GI, Schledzewski, K, Olsen, R, Falkowski, M, Kzhyshkowska, J, Carlsson, F, Johansson, S, Johansson, S, Smedsrød, B, Goerdt, S, McCourt, P

Exp Cell Res 2005
12473645 FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products

Tamura, Y, Adachi, H, Osuga, J, Ohashi, K, Yahagi, N, Sekiya, M, Okazaki, H, Tomita, S, Iizuka, Y, Shimano, H, Nagai, R, Kimura, S, Tsujimoto, M, Ishibashi, S

J Biol Chem 2003
Orthologous Events
Cite Us!