Reactome | STAB2:ligand is endocytosed

STAB2:ligand is endocytosed

Stable Identifier

R-HSA-2247511

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endocytic vesicle membrane, plasma membrane

ReviewStatus

5/5

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The STAB2:ligand complex is endocytosed (Tamura et al. 2003, Li et al. 2011). Endocytosis of stabilin-1 or stabilin-2 can occur independently of ligand binding, via clathrin (Hansen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15572036	Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding Hansen, B, Longati, P, Elvevold, K, Nedredal, GI, Schledzewski, K, Olsen, R, Falkowski, M, Kzhyshkowska, J, Carlsson, F, Johansson, S, Johansson, S, Smedsrød, B, Goerdt, S, McCourt, P	Exp Cell Res	2005
21030611	Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins Li, R, Oteiza, A, Sørensen, KK, McCourt, P, Olsen, R, Smedsrød, B, Svistounov, D	Am J Physiol Gastrointest Liver Physiol	2011
12473645	FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products Tamura, Y, Adachi, H, Osuga, J, Ohashi, K, Yahagi, N, Sekiya, M, Okazaki, H, Tomita, S, Iizuka, Y, Shimano, H, Nagai, R, Kimura, S, Tsujimoto, M, Ishibashi, S	J Biol Chem	2003