Reactome | NOTCH2 binds CNTN1

NOTCH2 binds CNTN1

Stable Identifier

R-HSA-2220816

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CNTN1 (F3, contactin-1) is a neuronal cell adhesion protein that can bind and activate NOTCH2, as well as NOTCH1, and these interactions are thought to play a role in oligodendrocyte maturation. While NOTCH1 activation by CNTN1 was shown to be deltex-dependent, the involvement of deltex in CNTN1-mediated activation of NOTCH2, although likely, has not been examined (Hu et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
14567914	F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation Small, D, Cui, XY, Ling, EA, Hirai, H, Pallen, CJ, Okano, H, Karsak, M, Xiao, ZC, Maciag, T, Ang, BT, Takeda, Y, Watanabe, K, Duka, T, Ng, YK, Hu, QD, Nakafuku, M, Sankar, N, Aster, JC, Chiba, S, Kopan, R, Schachner, M, Trifonova, R, Chia, W, Hu, WP	Cell	2003