Collagen type VII dimerization

Stable Identifier
R-HSA-2214324
Type
Reaction [binding]
Species
Homo sapiens
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Collagen VII triple-helices form an anti-parallel dimer, associating through disulfide bonds formed in a 60-nm overlap (NC2 domain) of the amino terminal triple helical ends. A portion of this region is proteolytically removed (Morris et al. 1986, Chen et al. 2001) prior to aggregation of dimers into anchoring fibrils (Lundstrum et al. 1986).

Literature References
PubMed ID Title Journal Year
3082888 The tissue form of type VII collagen is an antiparallel dimer

Morris, NP, Keene, DR, Glanville, RW, Bentz, H, Burgeson, RE

J Biol Chem 1986
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