Reactome | Release of endostatin-like peptides

Release of endostatin-like peptides

Stable Identifier

R-HSA-2213200

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Collagens XV and XVIII are basement membrane associated collagens that can be cleaved to generate the antiangiogenic peptides restin (endostatin-XV) and endostatin (endostatin-XVIII), respectively (O'Reilly et al. 1997, Ramachandran et al. 1997, Sasaki et al. 2000). Endostatin fragments of differing molecular size (14-30 kDa) have been identified in vivo. Furthermore the C-terminal domains of several other collagens (IV, VIII, XIX) have anti-angiogenic and anti-tumoral activities (Ricard-Blum & Ballut 2011). Several proteases are able to generate endostatin from collagen XVIII including MMP-3, -7, -9, -13 and -20 and cathepsins B, V, S and L (Heljasvaara et al. 2005, Ma et al. 2007, Veillard et al. 2011). Endostatin inhibits proliferation of endothelial cells, angiogenesis and tumor growth in vivo (O'Reilly et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
10966814	Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity Larsson, H, Hohenester, E, Tisi, D, Claesson-Welsh, L, Timpl, R, Sasaki, T	J Mol Biol	2000
9008168	Endostatin: an endogenous inhibitor of angiogenesis and tumor growth Vasios, G, Fukai, N, Lane, WS, O'Reilly, MS, Flynn, E, Boehm, T, Olsen, BR, Folkman, J, Birkhead, JR, Shing, Y	Cell	1997