MTMR4 binds phosphorylated SMAD2/3

Stable Identifier
R-HSA-2187405
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, early endosome membrane
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MTMR4 binds phosphorylated SMAD2/3
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A protein phosphatase MTMR4, residing in the early endosome membrane, binds phosphorylated SMAD2 and SMAD3 (Yu et al. 2010).

Literature References
PubMed ID Title Journal Year
20061380 MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes

Yu, J, Pan, L, Qin, X, Chen, H, Xu, Y, Chen, Y, Tang, H

J Biol Chem 2010
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Orthologous Events
MTMR4 binds phosphorylated SMAD2/3 (Caenorhabditis elegans)
MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)
MTMR4 binds phosphorylated SMAD2/3 (Drosophila melanogaster)
MTMR4 binds phosphorylated SMAD2/3 (Gallus gallus)
MTMR4 binds phosphorylated SMAD2/3 (Mus musculus)
MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)
MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)
MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-10)
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