MTMR4 binds phosphorylated SMAD2/3

Stable Identifier
R-HSA-2187405
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, early endosome membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MTMR4 binds phosphorylated SMAD2/3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A protein phosphatase MTMR4, residing in the early endosome membrane, binds phosphorylated SMAD2 and SMAD3 (Yu et al. 2010).

Literature References
PubMed ID Title Journal Year
20061380 MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes

Yu, J, Pan, L, Qin, X, Chen, H, Xu, Y, Chen, Y, Tang, H

J Biol Chem 2010
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
MTMR4 binds phosphorylated SMAD2/3 (Bos taurus)
MTMR4 binds phosphorylated SMAD2/3 (Caenorhabditis elegans)
MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)
MTMR4 binds phosphorylated SMAD2/3 (Drosophila melanogaster)
MTMR4 binds phosphorylated SMAD2/3 (Gallus gallus)
MTMR4 binds phosphorylated SMAD2/3 (Mus musculus)
MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)
MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)
MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-10)