SMAD3 binds STUB1 (CHIP)

Stable Identifier
R-HSA-2187375
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMAD3 binds STUB1 (CHIP)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
STUB1 (CHIP), an E3 ubiquitin ligase, binds SMAD3 irrespective of TGF-beta stimulation (Li et al. 2004, Xin et al. 2005).
Literature References
PubMed ID Title Journal Year
14701756 CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

Zhang, S, Fu, XY, Xin, H, Li, L, Zhang, X, Chang, Z, Chen, Y, Xu, X, Huang, M

Mol Cell Biol 2004
15781469 CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

Fu, XY, Xin, H, Li, L, Chang, Z, Rong, Y, Xu, X, Ning, H, Shang, Y, Wang, Y

J Biol Chem 2005
Participants
Input
Output
Participates
as an event of
Orthologous Events
SMAD3 binds STUB1 (CHIP) (Bos taurus)
SMAD3 binds STUB1 (CHIP) (Caenorhabditis elegans)
SMAD3 binds STUB1 (CHIP) (Canis familiaris)
SMAD3 binds STUB1 (CHIP) (Drosophila melanogaster)
SMAD3 binds STUB1 (CHIP) (Gallus gallus)
SMAD3 binds STUB1 (CHIP) (Mus musculus)
SMAD3 binds STUB1 (CHIP) (Rattus norvegicus)
SMAD3 binds STUB1 (CHIP) (Sus scrofa)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-09)
Cite Us!