SMAD2/3:SMAD4 heterotrimer binds SP1

Stable Identifier
R-HSA-2187309
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMAD2/3:SMAD4 heterotrimer binds SP1
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TGF-beta (TGFB1) stimulates formation of a complex of SP1 transcription factor and SMAD2/3:SMAD4 heterotrimer. SMAD2 and SMAD4 bind to SP1 directly, through their C- and N-terminus, respectively (Feng et al. 2000).

Literature References
PubMed ID Title Journal Year
11013220 Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

Lin, X, Feng, XH, Derynck, R

EMBO J 2000
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Orthologous Events
SMAD2/3:SMAD4 heterotrimer binds SP1 (Bos taurus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Caenorhabditis elegans)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Danio rerio)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Drosophila melanogaster)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-09)
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