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SMAD7:NEDD4L complex translocates to the cytosol
Stable Identifier
R-HSA-2176417
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)
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Binding of NEDD4L promotes translocation of SMAD7 to the cytosol (Kuratomi et al. 2005). This is based on experiments using recombinant mouse Smad7 and recombinant human NEDD4L.
Literature References
PubMed ID
Title
Journal
Year
15496141
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
Miyazono, K
,
Goto, K
,
Kuratomi, G
,
Shinozaki, M
,
Imamura, T
,
Komuro, A
,
Miyazawa, K
Biochem J
2005
Participants
Input
SMAD7:NEDD4L [nucleoplasm]
(Homo sapiens)
Output
SMAD7:NEDD4L [cytosol]
(Homo sapiens)
Participates
as an event of
Downregulation of TGF-beta receptor signaling (Homo sapiens)
Inferred From
Translocation of Smad7:NEDD4L complex to the cytosol (Homo sapiens)
Authored
Orlic-Milacic, M (2012-04-05)
Reviewed
Huang, T (2012-05-14)
Created
Orlic-Milacic, M (2012-04-02)
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