Reactome | SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7

SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7

Stable Identifier

R-HSA-2169050

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) ubiquitin ligases, recruited to TGF-beta receptor complex through interaction with SMAD7, ubiquitinate both SMAD7 and/or TGF-beta receptor I (TGFBR1), targeting the complex for degradation. This was inferred from experiments using a recombinant mouse Smad7 with recombinant human ubiquitin ligases and TGF-beta receptors.

Literature References

PubMed ID	Title	Journal	Year
11278251	Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation Ebisawa, T, Fukuchi, M, Murakami, G, Chiba, T, Tanaka, K, Imamura, T, Miyazono, K	J Biol Chem	2001
15496141	NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor Kuratomi, G, Komuro, A, Goto, K, Shinozaki, M, Miyazawa, K, Miyazono, K, Imamura, T	Biochem J	2005
11163210	Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation Kavsak, P, Rasmussen, RK, Causing, CG, Bonni, S, Zhu, H, Thomsen, GH, Wrana, JL	Mol Cell	2000