NOTCH3 binds DLL4

Stable Identifier
R-HSA-2168136
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of NOTCH3 receptor to DLL4 ligand has not been directly demonstrated. DLL4 and NOTCH3 are expressed on neighboring cells in retina (Claxton and Fruttiger 2004) and in endothelium/blood (Indraccolo et al. 2009), and DLL4 significantly and specifically increases NOTCH3 signaling (Indraccolo et al. 2009).

Literature References
PubMed ID Title Journal Year
19208840 Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy

Indraccolo, S, Minuzzo, S, Masiero, M, Pusceddu, I, Persano, L, Moserle, L, Reboldi, A, Favaro, E, Mecarozzi, M, Di Mario, G, Screpanti, I, Ponzoni, M, Doglioni, C, Amadori, A

Cancer Res 2009
15533827 Periodic Delta-like 4 expression in developing retinal arteries

Claxton, S, Fruttiger, M

Gene Expr Patterns 2004
Participants
Participant Of
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Go Biological Process
Orthologous Events
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