Binding of NOTCH3 receptor to DLL4 ligand has not been directly demonstrated. DLL4 and NOTCH3 are expressed on neighboring cells in retina (Claxton and Fruttiger 2004) and in endothelium/blood (Indraccolo et al. 2009), and DLL4 significantly and specifically increases NOTCH3 signaling (Indraccolo et al. 2009).
Claxton, S, Fruttiger, M
Pusceddu, I, Mecarozzi, M, Indraccolo, S, Amadori, A, Masiero, M, Minuzzo, S, Favaro, E, Screpanti, I, Reboldi, A, Di Mario, G, Ponzoni, M, Persano, L, Moserle, L, Doglioni, C
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