NOTCH3 binds DLL4

Stable Identifier
R-HSA-2168136
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NOTCH3 binds DLL4
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Binding of NOTCH3 receptor to DLL4 ligand has not been directly demonstrated. DLL4 and NOTCH3 are expressed on neighboring cells in retina (Claxton and Fruttiger 2004) and in endothelium/blood (Indraccolo et al. 2009), and DLL4 significantly and specifically increases NOTCH3 signaling (Indraccolo et al. 2009).
Literature References
PubMed ID Title Journal Year
15533827 Periodic Delta-like 4 expression in developing retinal arteries

Claxton, S, Fruttiger, M

Gene Expr Patterns 2004
19208840 Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy

Pusceddu, I, Mecarozzi, M, Indraccolo, S, Amadori, A, Masiero, M, Minuzzo, S, Favaro, E, Screpanti, I, Reboldi, A, Di Mario, G, Ponzoni, M, Persano, L, Moserle, L, Doglioni, C

Cancer Res 2009
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Event Information
Go Biological Process
Notch signaling pathway (0007219)
Orthologous Events
NOTCH3 binds DLL4 (Gallus gallus)
NOTCH3 binds DLL4 (Mus musculus)
NOTCH3 binds DLL4 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2012-03-23)
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