Reactome | ALOX5 oxidises 15S-HpETE to LXA4/B4

ALOX5 oxidises 15S-HpETE to LXA4/B4

Stable Identifier

R-HSA-2161917

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Arachidonate 5-lipoxygenase (ALOX5) (Ueda et al. 1987) converts 15S-hydroperoxy-eicosatetraenoic acid (15S-HpETE) into lipoxin A4 (LXA4) and B4 (LXB4) (Serhan et al. 1984A, Serhan et al. 1984B). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.

Literature References

PubMed ID	Title	Journal	Year
6089195	Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes Serhan, CN, Hamberg, M, Samuelsson, B	Proc Natl Acad Sci U S A	1984
6422933	Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes Serhan, CN, Hamberg, M, Samuelsson, B	Biochem Biophys Res Commun	1984
3579953	Lipoxin synthesis by arachidonate 5-lipoxygenase purified from porcine leukocytes Ueda, N, Yamamoto, S, Fitzsimmons, BJ, Rokach, J	Biochem Biophys Res Commun	1987
3770188	Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase Puustinen, T, Webber, SE, Nicolaou, KC, Haeggström, JZ, Serhan, CN, Samuelsson, B	FEBS Lett	1986

Participants

Input

x 2 15S-HpETE [cytosol]
O2 [cytosol]

Output

x 2 LXA4/B4 [cytosol]

Participates

as an event of

Biosynthesis of Lipoxins (LX) (Homo sapiens)

Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]

Physical Entity

ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)

Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)

Orthologous Events

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Bos taurus)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Danio rerio)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Dictyostelium discoideum)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Gallus gallus)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Mus musculus)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Rattus norvegicus)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Sus scrofa)