ALOX5 oxidises 15S-HpETE to LXA4/B4

Stable Identifier
R-HSA-2161917
Type
Reaction
Species
Homo sapiens
Compartment
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Arachidonate 5-lipoxygenase (ALOX5) (Ueda et al. 1987) converts 15S-hydroperoxy-eicosatetraenoic acid (15S-HpETE) into lipoxin A4 (LXA4) and B4 (LXB4) (Serhan et al. 1984A, Serhan et al. 1984B). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.

Literature References
PubMed ID Title Journal Year
6089195 Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes

Serhan, CN, Hamberg, M, Samuelsson, B

Proc Natl Acad Sci U S A 1984
6422933 Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes

Serhan, CN, Hamberg, M, Samuelsson, B

Biochem Biophys Res Commun 1984
3579953 Lipoxin synthesis by arachidonate 5-lipoxygenase purified from porcine leukocytes

Rokach, J, Ueda, N, Yamamoto, S, Fitzsimmons, BJ

Biochem Biophys Res Commun 1987
3770188 Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase

Nicolaou, KC, Webber, SE, Serhan, CN, Haeggström, JZ, Puustinen, T, Samuelsson, B

FEBS Lett 1986
Participants
Output
Participates
Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]

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