ALOX5 oxidises 15S-HpETE to LXA4/B4

Stable Identifier
R-HSA-2161917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arachidonate 5-lipoxygenase (ALOX5) (Ueda et al. 1987) converts 15S-hydroperoxy-eicosatetraenoic acid (15S-HpETE) into lipoxin A4 (LXA4) and B4 (LXB4) (Serhan et al. 1984A, Serhan et al. 1984B). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.

Literature References
PubMed ID Title Journal Year
6422933 Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes

Serhan, CN, Hamberg, M, Samuelsson, B

Biochem Biophys Res Commun 1984
6089195 Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes

Serhan, CN, Hamberg, M, Samuelsson, B

Proc Natl Acad Sci U S A 1984
3579953 Lipoxin synthesis by arachidonate 5-lipoxygenase purified from porcine leukocytes

Ueda, N, Yamamoto, S, Fitzsimmons, BJ, Rokach, J

Biochem Biophys Res Commun 1987
3770188 Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase

Puustinen, T, Webber, SE, Nicolaou, KC, Haeggström, JZ, Serhan, CN, Samuelsson, B

FEBS Lett 1986
Participants
Output
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
Physical Entity
Activity
Orthologous Events
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Created