Arachidonate 5-lipoxygenase (ALOX5) (Ueda et al. 1987) converts 15S-hydroperoxy-eicosatetraenoic acid (15S-HpETE) into lipoxin A4 (LXA4) and B4 (LXB4) (Serhan et al. 1984A, Serhan et al. 1984B). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.
Serhan, CN, Hamberg, M, Samuelsson, B
Rokach, J, Ueda, N, Yamamoto, S, Fitzsimmons, BJ
Nicolaou, KC, Webber, SE, Serhan, CN, Haeggström, JZ, Puustinen, T, Samuelsson, B
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
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