Reactome | ALOX5 oxidises 15S-HpETE to LXA4/B4

ALOX5 oxidises 15S-HpETE to LXA4/B4

Stable Identifier

R-HSA-2161917

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Arachidonate 5-lipoxygenase (ALOX5) (Ueda et al. 1987) converts 15S-hydroperoxy-eicosatetraenoic acid (15S-HpETE) into lipoxin A4 (LXA4) and B4 (LXB4) (Serhan et al. 1984A, Serhan et al. 1984B). One of the reaction intermediates of this process might be 5S,6S-epoxy-15S-hydroxy-7E,9E,11Z,13E-eicosatetraenoic acid (5,6-Ep-15S-HETE) (Puustinen et al. 1986). However, its generation from LTA4 is unclear but it can be hydrolysed to form the lipoxins.

Literature References

PubMed ID	Title	Journal	Year
6422933	Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes Serhan, CN, Hamberg, M, Samuelsson, B	Biochem Biophys Res Commun	1984
6089195	Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes Serhan, CN, Hamberg, M, Samuelsson, B	Proc Natl Acad Sci U S A	1984
3579953	Lipoxin synthesis by arachidonate 5-lipoxygenase purified from porcine leukocytes Ueda, N, Yamamoto, S, Fitzsimmons, BJ, Rokach, J	Biochem Biophys Res Commun	1987
3770188	Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase Puustinen, T, Webber, SE, Nicolaou, KC, Haeggström, JZ, Serhan, CN, Samuelsson, B	FEBS Lett	1986

Participants

Input

2 x 15S-HpETE [cytosol]
O2 [cytosol]

Output

2 x LXA4/B4 [cytosol]

Participant Of

hasEvent

Synthesis of Lipoxins (LX)

Catalyst Activity

Title

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]

Physical Entity

ALOX5:ALOX5AP:LTC4S [nuclear envelope]

Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (0016702)

Orthologous Events

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Bos taurus)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Canis familiaris)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Danio rerio)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Dictyostelium discoideum)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Gallus gallus)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Mus musculus)

ALOX5 oxidises 15S-HpETE to LXA4/B4 (Rattus norvegicus)