ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4

Stable Identifier
R-HSA-2161907
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nuclear envelope
ReviewStatus
5/5
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ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4
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Arachidonate 5-lipoxygenase (ALOX5) converts 15R-hydro-eicosatetraenoic acid (15R-HETE) to the epi-lipoxins, 15epi-lipoxin A4 (15epi-LXA4) and 15epi-lipoxin B4 (15epi-LXB4) (Claria & Serhan 1995). These epi-lipoxins have altered configuration at the C-15 hydroxyl but similar biological potency.
Literature References
PubMed ID Title Journal Year
7568157 Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

Clària, J, Serhan, CN

Proc Natl Acad Sci U S A 1995
Participants
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Output
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Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]

Physical Entity
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
Activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)
Orthologous Events
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Bos taurus)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Canis familiaris)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Dictyostelium discoideum)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Gallus gallus)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Mus musculus)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Rattus norvegicus)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Sus scrofa)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Xenopus tropicalis)
Authored
Williams, MG  (2012-02-24)
Reviewed
Hansen, TV  (2018-02-21)
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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