ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4

Stable Identifier
R-HSA-2161907
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arachidonate 5-lipoxygenase (ALOX5) converts 15R-hydro-eicosatetraenoic acid (15R-HETE) to the epi-lipoxins, 15epi-lipoxin A4 (15epi-LXA4) and 15epi-lipoxin B4 (15epi-LXB4) (Claria & Serhan 1995). These epi-lipoxins have altered configuration at the C-15 hydroxyl but similar biological potency.

Literature References
PubMed ID Title Journal Year
7568157 Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

ClĂ ria, J, Serhan, CN

Proc Natl Acad Sci U S A 1995
Participants
Participates
Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]

Orthologous Events
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