TXB2 is converted to 11dh-TXB2 by TXDH

Stable Identifier
R-HSA-2161732
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
NAD(+) + thromboxane B2 => 11-dehydro-thromboxane B2 + H(+) + NADH
ReviewStatus
5/5
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TXB2 is converted to 11dh-TXB2 by TXDH
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Thromboxane B2 (TXB2) undergoes dehydrogenation at C-11 to form 11-dehydro-thromboxane B2 (11dh-TXB2). The enzyme responsible for catalysis has been termed 11-dehydroxythromboxane B2 dehydrogenase (TXDH) (Kumlin & Granström 1986, Catella et al. 1986, Westlund et al. 1994). The human TXDH isoform has not been cloned but 11dh-TXB2 has been detected in various experiments.
Literature References
PubMed ID Title Journal Year
3823488 Radioimmunoassay for 11-dehydro-TXB2: a method for monitoring thromboxane production in vivo

Kumlin, M, Granström, E

Prostaglandins 1986
8200461 11-Hydroxythromboxane B2 dehydrogenase is identical to cytosolic aldehyde dehydrogenase

Westlund, P, Fylling, AC, Cederlund, E, Jörnvall, H

FEBS Lett 1994
3461463 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation

Catella, F, Healy, D, Lawson, JA, FitzGerald, GA

Proc Natl Acad Sci U S A 1986
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Output
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Catalyst Activity

11-hydroxythromboxane B2 dehydrogenase activity of TXDH [endoplasmic reticulum lumen]

Physical Entity
TXDH [endoplasmic reticulum lumen] (Homo sapiens)
Activity
11-hydroxythromboxane B2 dehydrogenase activity (GO:0036133)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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