Disassembly of tight junctions

Stable Identifier
R-HSA-2160931
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cell junction
ReviewStatus
5/5
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Disassembly of tight junctions
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Ubiquitination of RHOA by SMURF1 leads to disassembly of tight junctions, an important step in epithelial to mesenchymal transition.

Literature References
PubMed ID Title Journal Year
15761148 Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

Barrios-Rodiles, M, Zhang, Y, Wrana, JL, Wang, HR, Bose, R, Ozdamar, B

Science 2005
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Orthologous Events
Disassembly of tight junctions (Bos taurus)
Disassembly of tight junctions (Canis familiaris)
Disassembly of tight junctions (Danio rerio)
Disassembly of tight junctions (Drosophila melanogaster)
Disassembly of tight junctions (Gallus gallus)
Disassembly of tight junctions (Mus musculus)
Disassembly of tight junctions (Rattus norvegicus)
Disassembly of tight junctions (Sus scrofa)
Disassembly of tight junctions (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-03-05)
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