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Disassembly of tight junctions
Stable Identifier
R-HSA-2160931
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cell junction
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
Disassembly of tight junctions (Homo sapiens)
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Ubiquitination of RHOA by SMURF1 leads to disassembly of tight junctions, an important step in epithelial to mesenchymal transition.
Literature References
PubMed ID
Title
Journal
Year
15761148
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
Barrios-Rodiles, M
,
Zhang, Y
,
Wrana, JL
,
Wang, HR
,
Bose, R
,
Ozdamar, B
Science
2005
Participants
Input
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction]
(Homo sapiens)
Participates
as an event of
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
Orthologous Events
Disassembly of tight junctions (Bos taurus)
Disassembly of tight junctions (Caenorhabditis elegans)
Disassembly of tight junctions (Canis familiaris)
Disassembly of tight junctions (Danio rerio)
Disassembly of tight junctions (Drosophila melanogaster)
Disassembly of tight junctions (Gallus gallus)
Disassembly of tight junctions (Mus musculus)
Disassembly of tight junctions (Rattus norvegicus)
Disassembly of tight junctions (Sus scrofa)
Disassembly of tight junctions (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2012-04-05)
Reviewed
Huang, T (2012-05-14)
Created
Orlic-Milacic, M (2012-03-05)
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