Reactome | Interaction of integrin alphaXbeta2 with fibrin

Interaction of integrin alphaXbeta2 with fibrin

Stable Identifier

R-HSA-216082

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Interaction of integrin alphaXbeta2 with fibrin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Integrin alphaXbeta2 serves as a cell surface receptor for fibrinogen and plays an important role in leuckocyte functions including phagocytosis and migration.

Literature References

PubMed ID	Title	Journal	Year
10543983	Characteristics of fibrinogen binding to the domain of CD11c, an alpha subunit of p150,95 Nham, SU	Biochem Biophys Res Commun	1999
17339034	Critical residues of alphaX I-domain recognizing fibrinogen central domain Choi, J, Nham, SU, Lee, JH	Biochem Biophys Res Commun	2007