Interaction of integrin alphaXbeta2 with fibrin

Stable Identifier
R-HSA-216082
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of integrin alphaXbeta2 with fibrin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Integrin alphaXbeta2 serves as a cell surface receptor for fibrinogen and plays an important role in leuckocyte functions including phagocytosis and migration.

Literature References
PubMed ID Title Journal Year
17339034 Critical residues of alphaX I-domain recognizing fibrinogen central domain

Lee, JH, Choi, J, Nham, SU

Biochem Biophys Res Commun 2007
10543983 Characteristics of fibrinogen binding to the domain of CD11c, an alpha subunit of p150,95

Nham, SU

Biochem Biophys Res Commun 1999
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Interaction of integrin alphaXbeta2 with fibrin (Mus musculus)
Interaction of integrin alphaXbeta2 with fibrin (Rattus norvegicus)
Authored
Geiger, B  (2008-05-07)
Horwitz, AR  (2008-05-07)
Reviewed
Yamada, KM  (2008-05-07)
Humphries, MJ  (2008-05-07)
Hynes, R  (2008-05-07)
Created
Garapati, P V  (2008-03-11)