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ITGB6 [plasma membrane]
Stable Identifier
R-HSA-215951
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin beta-6
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)
Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
Elastic fibre formation (Homo sapiens)
Fibrillin-1 binds integrins (Homo sapiens)
Fibrilin-1:Fibrilin-binding integrins [plasma membrane] (Homo sapiens)
Fibrilin-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
Fibrilin-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
Molecules associated with elastic fibres (Homo sapiens)
Latent TGF-beta-1 binds integrins (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
Latent TGF-beta-3 binds integrins (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Latent TGF-beta-1 binds integrins (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
Latent TGF-beta-3 binds integrins (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGB6 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18564 ITGB6
Gene Names
ITGB6
Chain
signal peptide:1-21, chain:22-788
Reference Genes
BioGPS Gene:3694 ITGB6
COSMIC (genes):ITGB6 ITGB6
CTD Gene:3694 ITGB6
dbSNP Gene:3694 ITGB6
ENSEMBL:ENSG00000115221.12 ITGB6
HGNC:6161 ITGB6
KEGG Gene (Homo sapiens):3694 ITGB6
Monarch:3694 ITGB6
NCBI Gene:3694 ITGB6
OMIM:147558 ITGB6
UCSC:P18564 ITGB6
Reference Transcript
RefSeq:NM_000888.4 ITGB6
RefSeq:NM_001282353.1 ITGB6
RefSeq:NM_001282388.1 ITGB6
RefSeq:NM_001282355.1 ITGB6
Other Identifiers
0004760408
11748463_a_at
11759140_at
16904193
208083_3p_s_at
208083_PM_s_at
208083_s_at
208084_PM_at
208084_at
226535_PM_at
226535_at
2583466
2583467
2583468
2583472
2583474
2583475
2583476
2583482
2583483
2583486
2583502
2583506
2583507
2583508
2583509
2583510
2583511
2583512
2583513
3166267
3694
53160_at
8056184
881_at
A_23_P154217
GE57946
GO:0000902
GO:0001618
GO:0002376
GO:0005178
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005813
GO:0005815
GO:0005856
GO:0005886
GO:0005925
GO:0006954
GO:0006955
GO:0007155
GO:0007160
GO:0007179
GO:0007229
GO:0008305
GO:0009611
GO:0009615
GO:0009897
GO:0009986
GO:0010467
GO:0016020
GO:0016021
GO:0016477
GO:0023052
GO:0030054
GO:0030154
GO:0032991
GO:0033627
GO:0034685
GO:0038023
GO:0042060
GO:0043129
GO:0043226
GO:0043235
GO:0043588
GO:0046718
GO:0048286
GO:0048856
GO:0048870
GO:0055091
GO:0060022
GO:0060089
GO:0060348
GO:0060395
GO:0060435
GO:0061520
GO:0070161
GO:0070166
GO:0071479
GO:0071604
GO:0098772
GO:0140677
GO:1901388
HMNXSV003042631
Hs.57664.0.S1_3p_at
ILMN_1662635
ILMN_1789846
M35198_at
PH_hs_0003688
TC02002469.hg
g9966771_3p_at
g9966771_3p_s_at
Participates
as a component of
Integrin alphaVbeta6 [plasma membrane] (Homo sapiens)
Inferred To
pat-3 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ITGB6 [plasma membrane]
(Drosophila melanogaster)
itgb6 [plasma membrane]
(Xenopus tropicalis)
mys [plasma membrane]
(Drosophila melanogaster)
Itgb6 [plasma membrane]
(Mus musculus)
Itgb6 [plasma membrane]
(Rattus norvegicus)
ITGB6 [plasma membrane]
(Bos taurus)
ITGB6 [plasma membrane]
(Canis familiaris)
ITGB6 [plasma membrane]
(Danio rerio)
ITGB6 [plasma membrane]
(Gallus gallus)
ITGB6 [plasma membrane]
(Sus scrofa)
Itgbn [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001269282.1
,
NP_000879.2
,
NP_001269284.1
,
NP_001269317.1
Guide to Pharmacology - Targets
2460
OpenTargets
ENSG00000115221
GeneCards
P18564
HPA
ENSG00000115221-ITGB6
Ensembl
ENSP00000386367
,
ENSP00000386828
,
ENST00000409872
,
ENSP00000283249
,
ENST00000283249
,
ENSG00000115221
,
ENST00000409967
PRO
P18564
Pharos - Targets
P18564
Orphanet
22813
PDB
5FFG
,
5NEU
,
4UM9
,
5NET
,
4UM8
,
5FFO
,
5NER
,
5NEM
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