Growing HA is extruded from the cell by ABCC5

Stable Identifier
R-HSA-2142859
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Growing HA is extruded from the cell by ABCC5
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As hyaluronan (HA) is synthesised, it is continually extruded from the cell. While there is evidence that silencing of the ABC transporter C5 (ABCC5), also called multidrug resistance-associated protein 5 (MRP5), affects HA export (Schulz et al. 2007), HA is produced by HA synthases (HAS) 1,2,3 in a combined process of synthesis and membrane translocation (reviewed in e.g. Siiskonen et al., 2015).
Literature References
PubMed ID Title Journal Year
17540771 Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP

Schulz, T, Schumacher, U, Prehm, P

J Biol Chem 2007
25699059 Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

Siiskonen, H, Oikari, S, Pasonen-Seppänen, S, Rilla, K

Front Immunol 2015
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
carbohydrate derivative transport (1901264)
Catalyst Activity

transmembrane transporter activity of ABCC5 [plasma membrane]

Physical Entity
ABCC5 [plasma membrane] (Homo sapiens)
Activity
transmembrane transporter activity (GO:0022857)
Orthologous Events
Growing HA is extruded from the cell by ABCC5 (Bos taurus)
Growing HA is extruded from the cell by ABCC5 (Caenorhabditis elegans)
Growing HA is extruded from the cell by ABCC5 (Canis familiaris)
Growing HA is extruded from the cell by ABCC5 (Danio rerio)
Growing HA is extruded from the cell by ABCC5 (Dictyostelium discoideum)
Growing HA is extruded from the cell by ABCC5 (Gallus gallus)
Growing HA is extruded from the cell by ABCC5 (Mus musculus)
Growing HA is extruded from the cell by ABCC5 (Rattus norvegicus)
Growing HA is extruded from the cell by ABCC5 (Sus scrofa)
Growing HA is extruded from the cell by ABCC5 (Xenopus tropicalis)
Authored
Jassal, B  (2012-02-24)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2012-02-24)
Cite Us!