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HPGD [cytosol]
Stable Identifier
R-HSA-2142677
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
15-hydroxyprostaglandin dehydrogenase (NAD+), PGDH_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of D-series resolvins (Homo sapiens)
HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Homo sapiens)
HPGD dimer [cytosol] (Homo sapiens)
HPGD [cytosol] (Homo sapiens)
Biosynthesis of EPA-derived SPMs (Homo sapiens)
Biosynthesis of E-series 18(S)-resolvins (Homo sapiens)
HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Homo sapiens)
HPGD dimer [cytosol] (Homo sapiens)
HPGD [cytosol] (Homo sapiens)
Biosynthesis of Lipoxins (LX) (Homo sapiens)
LXA4 is oxidised to 15k-LXA4 by HPGD (Homo sapiens)
HPGD dimer [cytosol] (Homo sapiens)
HPGD [cytosol] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)
HPGD dimer [cytosol] (Homo sapiens)
HPGD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15428 HPGD
Gene Names
HPGD, PGDH1, SDR36C1
Chain
chain:1-266
Reference Genes
BioGPS Gene:3248 HPGD
COSMIC (genes):HPGD HPGD
CTD Gene:3248 HPGD
dbSNP Gene:3248 HPGD
ENSEMBL:ENSG00000164120 HPGD
HGNC:5154 HPGD
Monarch:3248 HPGD
NCBI Gene:3248 HPGD
OMIM:601688 HPGD
UCSC:P15428 HPGD
Reference Transcript
RefSeq:NM_001145816.2 HPGD
RefSeq:NM_001256307.1 HPGD
RefSeq:NM_001256301.1 HPGD
RefSeq:NM_000860.5 HPGD
RefSeq:NM_001256305.1 HPGD
RefSeq:NM_001256306.1 HPGD
Other Identifiers
11741499_x_at
11743655_a_at
11743656_a_at
11743657_x_at
11748513_x_at
11750517_x_at
11753601_x_at
11758083_s_at
16981606
203913_PM_s_at
203913_s_at
203914_PM_x_at
203914_x_at
211548_PM_s_at
211548_s_at
211549_PM_s_at
211549_s_at
2794407
2794409
2794410
2794411
2794412
2794413
2794414
2794415
2794416
2794417
2794422
2794423
2794424
2794425
2794426
2794427
2794428
2794432
2794435
2794436
2794437
2794438
2794439
3248
32570_at
37322_s_at
37323_r_at
70234_at
70258_at
8103769
A_21_P0012814
A_23_P213050
A_24_P71904
GE525577
GE57789
GE85255
GO:0001822
GO:0003824
GO:0004957
GO:0005615
GO:0005654
GO:0005737
GO:0005829
GO:0006629
GO:0006693
GO:0007179
GO:0007565
GO:0007567
GO:0016323
GO:0016404
GO:0016491
GO:0016616
GO:0019372
GO:0022414
GO:0030728
GO:0032355
GO:0032496
GO:0042802
GO:0043065
GO:0043226
GO:0045471
GO:0045786
GO:0048856
GO:0051287
GO:0060089
GO:0070062
GO:0070403
GO:0070493
GO:0097070
GO:1904707
GO:1905828
HMNXSV003010180
HMNXSV003027265
HMNXSV003041189
Hs.77348.0.S1_3p_a_at
ILMN_2166457
L76465_at
PH_hs_0027695
PH_hs_0034040
TC04001753.hg
TC04002840.hg
g1203981_3p_a_at
g2047312_3p_a_at
p12537
Participates
as a component of
HPGD dimer [cytosol] (Homo sapiens)
Inferred To
zgc:77077 [cytosol]
(Danio rerio)
hpgd [cytosol]
(Xenopus tropicalis)
Dmel\CG18814 [cytosol]
(Drosophila melanogaster)
Dmel\CG4842 [cytosol]
(Drosophila melanogaster)
HPGD [cytosol]
(Bos taurus)
HPGD [cytosol]
(Canis familiaris)
HPGD [cytosol]
(Drosophila melanogaster)
HPGD [cytosol]
(Gallus gallus)
HPGD [cytosol]
(Mus musculus)
HPGD [cytosol]
(Rattus norvegicus)
HPGD [cytosol]
(Sus scrofa)
Homologues of HPGD [cytosol]
(Drosophila melanogaster)
Cross References
Guide to Pharmacology - Targets
1384
ENSEMBL
ENST00000422112
,
ENST00000510901
,
ENST00000542498
,
ENSP00000296521
,
ENSP00000422418
,
ENST00000296522
,
ENST00000296521
,
ENSP00000398720
,
ENST00000541923
,
ENSP00000443644
,
ENSP00000438017
,
ENSP00000296522
OpenTargets
ENSG00000164120
HPA
ENSG00000164120-HPGD
ZINC - Substances
PGDH_HUMAN
ZINC target
P15428
PRO
P15428
Pharos - Targets
P15428
Orphanet
HPGD
ZINC - Predictions - Purchasable
PGDH_HUMAN
HMDB Protein
HMDBP00078
PDB
8CWL
,
8FD8
,
2GDZ
,
8CVN
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