Transport of MHC II:Ii complex to plasma membrane

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The newly formed MHC II-Ii complex exits the TGN and ultimately is delivered to late-endosome/lysosome compartments. A proportion of the nonameric complex traffics directly from the TGN to these compartments, while a substantial population follow the indirect pathway involving transport from the TGN to the plasma membrane, followed by endocytic delivery to early endosomes, late endosomes, and finally lysosomes (McCormick et al. 2005). Transport carrier vesicles may traffic the cargo MHC II-Ii complex from the TGN to the plasma membrane.
Literature References
PubMed ID Title Journal Year
8397411 Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization

Teletski, CL, Roche, PA, Long, EO, Stang, E, Bakke, O

Proc Natl Acad Sci U S A 1993
10540230 Cell surface expression and metabolism of major histocompatibility complex class II invariant chain (CD74) by diverse cell lines

Mattes, MJ, Goldenberg, DM, Hansen, HJ, Ong, GL

Immunology 1999
16824007 The formation of TGN-to-plasma-membrane transport carriers

Malhotra, V, Bard, F

Annu Rev Cell Dev Biol 2006
14731593 Targeting of membrane proteins to endosomes and lysosomes

Sandoval, IV, Bakke, O

Trends Cell Biol 1994
Orthologous Events
Cite Us!