Reactome | Transport of MHC II:Ii complex to plasma membrane

Transport of MHC II:Ii complex to plasma membrane

Stable Identifier

R-HSA-2130378

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

transport vesicle membrane, trans-Golgi network membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Transport of MHC II:Ii complex to plasma membrane

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The newly formed MHC II-Ii complex exits the TGN and ultimately is delivered to late-endosome/lysosome compartments. A proportion of the nonameric complex traffics directly from the TGN to these compartments, while a substantial population follow the indirect pathway involving transport from the TGN to the plasma membrane, followed by endocytic delivery to early endosomes, late endosomes, and finally lysosomes (McCormick et al. 2005). Transport carrier vesicles may traffic the cargo MHC II-Ii complex from the TGN to the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
8397411	Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization Teletski, CL, Roche, PA, Long, EO, Stang, E, Bakke, O	Proc Natl Acad Sci U S A	1993
10540230	Cell surface expression and metabolism of major histocompatibility complex class II invariant chain (CD74) by diverse cell lines Mattes, MJ, Goldenberg, DM, Hansen, HJ, Ong, GL	Immunology	1999
16824007	The formation of TGN-to-plasma-membrane transport carriers Malhotra, V, Bard, F	Annu Rev Cell Dev Biol	2006
14731593	Targeting of membrane proteins to endosomes and lysosomes Sandoval, IV, Bakke, O	Trends Cell Biol	1994