Association of DFF with alpha:beta importin

Stable Identifier
R-HSA-211191
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Association of DFF with alpha:beta importin
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The translocation of the DFF complex from the cytoplasm to the nucleus is mediated by the importin alfa/beta heterodimer. Both DFF40 and DFF45 possess NLS at their C-termini that interact directly with the importin alfa/beta heterodimer. However, DFF complex binds more tightly compared with the individual subunits and C-termini of both subunits are required for DFF nuclear import (Neimanis et al., 2007).
Literature References
PubMed ID Title Journal Year
17938174 Sequence elements in both subunits of the DNA fragmentation factor are essential for its nuclear transport

Kahle, J, Neimanis, S, Doenecke, D, Albig, W

J Biol Chem 2007
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Orthologous Events
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Association of DFF with alpha:beta importin (Mus musculus)
Association of DFF with alpha:beta importin (Rattus norvegicus)
Association of DFF with alpha:beta importin (Sus scrofa)
Association of DFF with alpha:beta importin (Xenopus tropicalis)
Authored
Matthews, L  (2008-01-29)
Reviewed
Widlak, P  (2008-05-08)
Created
Matthews, L  (2008-01-29)
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