Cleavage of DFF45 (224) by caspase-3

Stable Identifier
R-HSA-211186
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Cleavage of DFF45 (224) by caspase-3
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Caspase-3 cleaves DFF45 between residues 224,225.

Literature References
PubMed ID Title Journal Year
9108473 DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

Liu, X, Slaughter, C, Wang, X, Zou, H

Cell 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-3 [nucleoplasm]

Physical Entity
active caspase-3 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Cleavage of DFF45 (224) by caspase-3 (Bos taurus)
Cleavage of DFF45 (224) by caspase-3 (Canis familiaris)
Cleavage of DFF45 (224) by caspase-3 (Danio rerio)
Cleavage of DFF45 (224) by caspase-3 (Drosophila melanogaster)
Cleavage of DFF45 (224) by caspase-3 (Gallus gallus)
Cleavage of DFF45 (224) by caspase-3 (Mus musculus)
Cleavage of DFF45 (224) by caspase-3 (Rattus norvegicus)
Cleavage of DFF45 (224) by caspase-3 (Sus scrofa)
Authored
Matthews, L  (2008-01-29)
Reviewed
Widlak, P  (2008-05-08)
Created
Matthews, L  (2008-01-29)
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