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CYP4F2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-211016
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 4F2, CPF2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Eicosanoids (Homo sapiens)
CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F3 20-hydroxylates LTB4 (Homo sapiens)
Cytochrome P450 (CYP4F3 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F8 19-hydroxylates PGH2 (Homo sapiens)
Cytochrome P450 (CYP4F8 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
Fatty acids (Homo sapiens)
CYP4A11 12-hydroxylates DDCX (Homo sapiens)
Cytochrome P450 (CYP4A11 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
CYP4B1 12-hydroxylates ARA (Homo sapiens)
Cytochrome P450 (CYP4B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F12 18-hydroxylates ARA (Homo sapiens)
Cytochrome P450 (CYP4F12 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
Miscellaneous substrates (Homo sapiens)
CYP4F11 16-hydroxylates 3OH-PALM (Homo sapiens)
Cytochrome P450 (CYP4F11 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Homo sapiens)
Arachidonate is hydroxylated to 20-HETE by CYP(3) (Homo sapiens)
CYP(3) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)
Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)
Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP4F2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78329 CYP4F2
Gene Names
CYP4F2
Chain
propeptide:1-4, chain:5-520
Reference Genes
BioGPS Gene:8529 CYP4F2
COSMIC (genes):CYP4F2 CYP4F2
CTD Gene:8529 CYP4F2
dbSNP Gene:8529 CYP4F2
ENSEMBL:ENSG00000186115 CYP4F2
ENSEMBL_homo_sapiens_GENE:ENSG00000186115.13 CYP4F2
HGNC:2645 CYP4F2
KEGG Gene (Homo sapiens):8529 CYP4F2
Monarch:8529 CYP4F2
NCBI Gene:8529 CYP4F2
OMIM:604426 CYP4F2
UCSC:P78329 CYP4F2
Reference Transcript
RefSeq:NM_001082.4 CYP4F2
Other Identifiers
11727963_x_at
11727964_x_at
11733296_s_at
11749604_s_at
11749758_s_at
11753371_a_at
11753372_x_at
1305_s_at
1350_at
16869942
206514_3p_s_at
206514_PM_s_at
206514_s_at
210452_3p_x_at
210452_PM_x_at
210452_x_at
3823317
3823323
3823327
3823330
3823334
3853610
3853611
3853612
3853613
3853614
3853616
3853617
3853620
3853623
3853624
3853625
3853626
3853628
3853630
3853631
3853632
3853674
3853717
8035083
8529
A_24_P168494
A_24_P168495
A_33_P3359017
D12620_s_at
GE80980
GO:0000038
GO:0001676
GO:0003013
GO:0003014
GO:0003091
GO:0003095
GO:0003824
GO:0004497
GO:0005506
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006629
GO:0006631
GO:0006690
GO:0006691
GO:0006766
GO:0006805
GO:0007596
GO:0008217
GO:0008392
GO:0010430
GO:0016020
GO:0016324
GO:0016491
GO:0016705
GO:0016709
GO:0018685
GO:0019369
GO:0019373
GO:0020037
GO:0032304
GO:0032305
GO:0036101
GO:0042060
GO:0042360
GO:0042361
GO:0042376
GO:0042377
GO:0043226
GO:0043231
GO:0046872
GO:0050051
GO:0052869
GO:0052871
GO:0052872
GO:0055065
GO:0055078
GO:0070330
GO:0097258
GO:0097259
GO:0097267
GO:0102033
HMNXSV003015031
HMNXSV003057778
ILMN_1729439
PH_hs_0028678
TC19001261.hg
U02388_at
g391715_3p_s_at
g529642_3p_s_at
Participates
as a member of
CYP(3) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP4B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP4F12 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP4A11 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP4F8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP4F3 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP4F11 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
CYP4F3 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
CYP4F2 [endoplasmic reticulum membrane]
(Bos taurus)
CYP4F2 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP4F2 [endoplasmic reticulum membrane]
(Danio rerio)
CYP4F2 [endoplasmic reticulum membrane]
(Mus musculus)
CYP4F2 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP4F2 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001073.3
ZINC - World Drugs
CP4F2_HUMAN
Guide to Pharmacology - Targets
1344
OpenTargets
ENSG00000186115
ZINC - FDA approved
CP4F2_HUMAN
ZINC - Substances
CP4F2_HUMAN
ZINC target
P78329
PRO
P78329
IntEnz
1.14.14.78
,
1.14.14.79
GeneCards
P78329
HPA
ENSG00000186115-CYP4F2
Ensembl
ENST00000221700
,
ENSP00000221700
,
ENSG00000186115
Pharos - Targets
P78329
ZINC - Predictions - Purchasable
CP4F2_HUMAN
HMDB Protein
HMDBP01013
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:Q96QE2 SLC2A13
1
SLC2A13 [plasma membrane]
(R-HSA-429102)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q9NX18 SDHAF2
1
SDHAF2 [mitochondrial matrix]
(R-HSA-9854689)
0.556
3
UniProt:O15173 PGRMC2
4
PGRMC2 [nuclear envelope]
(R-HSA-9707674)
PGRMC2 [nucleoplasm]
(R-HSA-9707859)
PGRMC2 [endoplasmic reticulum membrane]
(R-HSA-9714349)
PGRMC2 [endosome membrane]
(R-HSA-9715090)
0.556
3
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