Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SLC1A3 [plasma membrane]
Stable Identifier
R-HSA-210520
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EAAT1
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
SLC1A3 [plasma membrane] (Homo sapiens)
Neurotransmitter uptake and metabolism In glial cells (Homo sapiens)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Homo sapiens)
glutamate uptake by astrocytes (Homo sapiens)
Astrocytic EAATs [plasma membrane] (Homo sapiens)
SLC1A3 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
SLC1A3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43003 SLC1A3
Gene Names
SLC1A3, EAAT1, GLAST, GLAST1
Chain
chain:1-542
Reference Genes
BioGPS Gene:6507 SLC1A3
COSMIC (genes):SLC1A3 SLC1A3
CTD Gene:6507 SLC1A3
dbSNP Gene:6507 SLC1A3
ENSEMBL:ENSG00000079215 SLC1A3
HGNC:10941 SLC1A3
KEGG:hsa:6507 SLC1A3
Monarch:6507 SLC1A3
NCBI Gene:6507 SLC1A3
OMIM:600111 SLC1A3
UCSC:P43003 SLC1A3
Reference Transcript
RefSeq:NM_001289940.1 SLC1A3
RefSeq:NM_001166695.2 SLC1A3
RefSeq:NM_004172.4 SLC1A3
RefSeq:XM_005248342.2 SLC1A3
Other Identifiers
11726251_a_at
11726252_a_at
11752464_a_at
11760069_at
11762224_at
1566624_3p_at
1566624_PM_at
1566624_at
1569054_PM_at
1569054_at
16984056
202800_PM_at
202800_at
2806650
2806651
2806652
2806653
2806654
2806655
2806656
2806657
2806658
2806659
2806661
2806662
2806663
2806664
2806665
2806666
2806667
2806668
2806674
2806675
2806676
2806677
2806678
2806679
2806681
2806695
2806696
2806697
2806698
2806699
2806700
2806701
2806702
2806703
2806704
2806705
2806706
2806707
2806708
2806709
2806710
2806711
2806712
2806713
2806714
2806715
2806716
2806717
2806718
2806719
2806720
2806721
2806723
2806724
2806725
2806726
2806728
2806730
2806747
2806749
2806751
2806753
2806755
2806757
31656_at
36609_at
6507
75246_s_at
8104930
82497_at
82500_g_at
A_14_P109135
A_14_P200970
A_14_P201874
A_21_P0000065
A_23_P250963
A_24_P286114
A_33_P3567892
D26443_at
GE57139
GE851312
GO:0001504
GO:0003013
GO:0005215
GO:0005313
GO:0005314
GO:0005515
GO:0005886
GO:0006520
GO:0006811
GO:0006836
GO:0006865
GO:0006883
GO:0007268
GO:0007605
GO:0009410
GO:0009416
GO:0009449
GO:0009611
GO:0009925
GO:0009986
GO:0015172
GO:0015175
GO:0015179
GO:0015293
GO:0015501
GO:0015804
GO:0015813
GO:0016020
GO:0016595
GO:0016597
GO:0021545
GO:0023052
GO:0031223
GO:0031410
GO:0042995
GO:0043005
GO:0043025
GO:0043226
GO:0045202
GO:0046677
GO:0046872
GO:0048471
GO:0048667
GO:0048856
GO:0050806
GO:0050877
GO:0050885
GO:0051938
GO:0055085
GO:0070633
GO:0070779
GO:0071314
GO:0071805
GO:0071944
GO:0098712
GO:0098796
GO:0140009
GO:0150104
GO:1902475
GO:1902476
HMNXSV003010245
HMNXSV003020653
HMNXSV003053257
Hs2.367736.1.S1_3p_at
Hs2.367736.1.S1_3p_x_at
Hs2.400248.1.S1_3p_at
ILMN_1852343
PH_hs_0032928
g4759125_3p_at
Participates
as a candidate of
Astrocytic EAATs [plasma membrane] (Homo sapiens)
as a member of
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
Other forms of this molecule
SLC1A3 P290R [plasma membrane]
SLC1A3 C186S [plasma membrane]
Inferred To
slc1a3 [plasma membrane]
(Xenopus tropicalis)
Eaat1 [plasma membrane]
(Drosophila melanogaster)
glt-1 [plasma membrane]
(Caenorhabditis elegans)
glt-5 [plasma membrane]
(Caenorhabditis elegans)
SLC1A3 [plasma membrane]
(Bos taurus)
SLC1A3 [plasma membrane]
(Caenorhabditis elegans)
SLC1A3 [plasma membrane]
(Gallus gallus)
SLC1A3 [plasma membrane]
(Mus musculus)
SLC1A3 [plasma membrane]
(Rattus norvegicus)
SLC1A3 [plasma membrane]
(Sus scrofa)
Homologues of SLC1A3 [plasma membrane]
(Caenorhabditis elegans)
glt-7 [plasma membrane]
(Caenorhabditis elegans)
glt-3 [plasma membrane]
(Caenorhabditis elegans)
slc1a3b [plasma membrane]
(Danio rerio)
GLAST [plasma membrane]
(Canis familiaris)
glt-6 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_005248399.1
,
NP_001160167.1
,
NP_004163.3
,
NP_001276869.1
Guide to Pharmacology - Targets
868
OpenTargets
ENSG00000079215
ENSEMBL
ENSP00000506424
,
ENSP00000505238
,
ENST00000680125
,
ENSP00000371343
,
ENSP00000265113
,
ENST00000679983
,
ENST00000680318
,
ENST00000679992
,
ENSP00000505850
,
ENST00000265113
,
ENST00000681926
,
ENSP00000506585
,
ENSP00000505057
,
ENST00000381918
ZINC - Substances
EAA1_HUMAN
ZINC target
P43003
PRO
P43003
PDB
5MJU
,
5LLU
,
5LM4
,
7NPW
,
5LLM
HPA
ENSG00000079215-SLC1A3
Pharos - Targets
P43003
Orphanet
SLC1A3
ZINC - Predictions - Purchasable
EAA1_HUMAN
HMDB Protein
HMDBP03133
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text