Alpha v beta 3 integrin is one of the potential heterophilic ligands of PECAM-1 that is involved in down-regulation of T-cell responses. The heterophilic interaction of alpha v beta 3 integrin on endothelial cells with PEACAM-1 on leukocytes increases the adhesive function of beta integrins on T cells, monocytes, neutrophils and NK cells suggesting that leukocyte PEACAM-1 act as a signaling molecule.
Imhof, BA, Bachmann, F, Piali, L, Uherek, C, Dunon, D, Gisler, RH, Hammel, P
Buckley, CD, Brown, EJ, Simmons, DL, Blystone, SD, Newton, JP, Doyonnas, R, Watt, SM
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