Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src

Stable Identifier
R-HSA-210291
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules.
Literature References
PubMed ID Title Journal Year
10858437 Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.

Cicmil, M, Thomas, JM, Sage, T, Barry, FA, Leduc, M, Bon, C, Gibbins, JM

J Biol Chem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Src family tyrosine kinases (SFKs) [cytosol]

Physical Entity
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Canis familiaris)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Danio rerio)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Gallus gallus)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Mus musculus)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Rattus norvegicus)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Sus scrofa)
Authored
de Bono, B  (2008-02-26)
Garapati, P V  (2008-02-26)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2008-01-10)
Cite Us!