PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules.
Barry, FA, Gibbins, JM, Thomas, JM, Sage, T, Cicmil, M, Bon, C, Leduc, M
protein tyrosine kinase activity of Src family tyrosine kinases (SFKs) [cytosol]
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