Reactome | Interaction of DAP12 and NKp44

Interaction of DAP12 and NKp44

Stable Identifier

R-HSA-210273

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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NKp44 is a natural cytotoxicity receptor (NCR) family member selectively expressed by IL-2-activated NK cells. It is a transmembrane receptor involved in recognizing unidentified non-MHC ligands on tumor cells, mediating tumor cell lysis by activated NK cells. NKp44 is coupled to cytoplasmic signal transduction machinery via association with DAP12. Lysine-183 in the transmembrane region of NKp44 may be involved in the association with DAP12. The interaction with DAP12 influences NKp44 surface expression and hence NK cell activation (Campbell et al. 2004, Cantoni et al. 1999, Vitale et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
10049942	NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily Parolini, S, Malaspina, A, Vitale, M, Cantoni, C, Bottino, C, Moretta, L, Augugliaro, R, Pessino, A, Moretta, A, Biassoni, R	J Exp Med	1999
14707061	NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence Kikuchi-Maki, A, Yusa, S, Catina, TL, Campbell, KS	J Immunol	2004
9625766	NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis Bottino, C, Sivori, S, Moretta, A, Moretta, L, Sanseverino, L, Augugliaro, R, Marcenaro, E, Castriconi, R, Vitale, M	J. Exp. Med.	1998