Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA

Stable Identifier
R-HSA-2066780
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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3-hydroxy tetracosahexaenoyl-CoA undergoes dehydrogenation to form 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA, catalysed by DBP. DBP is a bifunctional enzyme, involved in the hydration of a variety of trans-2,3-dehydroacyl-CoA's but also mediating dehydrogenation of a variety of 3-hydroxyacyl-CoA's (Jiang et al. 1997).

Literature References
PubMed ID Title Journal Year
11734571 Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Ferdinandusse, S, Denis, S, Mooijer, PA, Zhang, Z, Reddy, JK, Spector, AA, Wanders, RJ

J Lipid Res 2001
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA

J Lipid Res 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
long-chain-enoyl-CoA hydratase activity of HSD17B4 dimer [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Authored
Created