Reactome | Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA

Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA

Stable Identifier

R-HSA-2066780

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

3-hydroxy tetracosahexaenoyl-CoA undergoes dehydrogenation to form 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA, catalysed by DBP. DBP is a bifunctional enzyme, involved in the hydration of a variety of trans-2,3-dehydroacyl-CoA's but also mediating dehydrogenation of a variety of 3-hydroxyacyl-CoA's (Jiang et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
8656081	Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA	J Lipid Res	1995
11734571	Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid Ferdinandusse, S, Denis, S, Mooijer, PA, Zhang, Z, Reddy, JK, Spector, AA, Wanders, RJA	J Lipid Res	2001