Reactome | SREBP1A,1C,2 binds Importin beta-1

SREBP1A,1C,2 binds Importin beta-1

Stable Identifier

R-HSA-2065550

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SREBF1A,1C,2 binds Importin beta-1

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SREBP2 dimer (also called SREBF2 dimer) and, by inference SREBP1A,1C dimer, binds Importin beta-1 via the helix-loop-helix leucine zipper domain of SREBP1A,1C,2 (Nagoshi et al. 1999, Di Pardo et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
31875875	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import Di Pardo, A, Monyror, J, Morales, LC, Kadam, V, Lingrell, S, Maglione, V, Wozniak, RW, Sipione, S	Hum Mol Genet	2020
10397761	Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip Nagoshi, E, Imamoto, N, Sato, R, Yoneda, Y	Mol Biol Cell	1999