SREBP1A,1C,2 binds Importin beta-1

Stable Identifier
R-HSA-2065550
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
SREBF1A,1C,2 binds Importin beta-1
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SREBP2 dimer (also called SREBF2 dimer) and, by inference SREBP1A,1C dimer, binds Importin beta-1 via the helix-loop-helix leucine zipper domain of SREBP1A,1C,2 (Nagoshi et al. 1999, Di Pardo et al. 2020).

Literature References
PubMed ID Title Journal Year
10397761 Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip

Nagoshi, E, Imamoto, N, Sato, R, Yoneda, Y

Mol Biol Cell 1999
31875875 Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import

Di Pardo, A, Monyror, J, Morales, LC, Kadam, V, Lingrell, S, Maglione, V, Wozniak, RW, Sipione, S

Hum Mol Genet 2020
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