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SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers
Stable Identifier
R-HSA-2065549
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SREBF1A,1C,2 binds SREBF1A,1C,2 forming dimers
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The N-terminal domains of SREBPs (SREBP1A/1C/2, SREBFs) dimerize via interaction of their helix-loop-helix leucine zipper domains (Nagoshi and Yoneda 2001).
Literature References
PubMed ID
Title
Journal
Year
11283257
Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta
Yoneda, Y
,
Nagoshi, E
Mol Cell Biol
2001
Participants
Input
x 2
SREBF1A,1C,2 cleaved by S2P [cytosol]
(Homo sapiens)
Output
SREBP1A,1C,2 dimer [cytosol]
(Homo sapiens)
Participates
as an event of
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Orthologous Events
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Bos taurus)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Caenorhabditis elegans)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Canis familiaris)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Danio rerio)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Drosophila melanogaster)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Gallus gallus)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Mus musculus)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Rattus norvegicus)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Sus scrofa)
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Xenopus tropicalis)
Authored
May, B (2012-01-23)
Reviewed
Liang, G (2012-08-26)
Created
May, B (2012-01-24)
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