Reactome | Interaction of other tyrosine kinases with p-KIT

Interaction of other tyrosine kinases with p-KIT

Stable Identifier

R-HSA-205328

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Interaction of other tyrosine kinases with p-KIT

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Cytoplasmic tyrosine kinases such as CHK1 (Csk homologous kinase or MATK), FER and FES associate with p-KIT upon SCF stimulation (Price et al, 19997; Jhun et al, 1995; Craig AW, Greer PA, 2002). TEC has been demonstrated to associate with KIT constitutively and is activated by ligand stimulation (Tang et a l. 1994).

Literature References

PubMed ID	Title	Journal	Year
12192036	Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells Craig, AW, Greer, PA	Mol Cell Biol	2002
9038210	Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes Price, DJ, Rivnay, B, Fu, Y, Jiang, S, Avraham, S, Avraham, H	J Biol Chem	1997
7536744	The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit Jhun, BH, Rivnay, B, Price, D, Avraham, H	J Biol Chem	1995
10679268	Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains Masuhara, M, Nagao, K, Nishikawa, M, Sasaki, M, Yoshimura, A, Osawa, M	Biochem Biophys Res Commun	2000
16129412	Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor Roskoski, R Jr	Biochem Biophys Res Commun	2005
7526158	Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding Tang, B, Mano, H, Yi, T, Ihle, JN	Mol Cell Biol	1994