JNK phosphorylates BIM, BAD and other targets

Stable Identifier
R-HSA-205075
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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JNK phosphorylates BIM, BAD and other targets
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Once activated, JNK phosphorylates targets in cytoplasm, including BIM and BAD that promote the release of cytochrome c and activation of caspases 9, 6 and 3.
Literature References
PubMed ID Title Journal Year
14673001 Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad

Bhakar, AL, Howell, JL, Paul, CE, Salehi, AH, Becker, EB, Said, F, Bonni, A, Barker, PA

J Neurosci 2003
15470142 Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis

Becker, EB, Howell, J, Kodama, Y, Barker, PA, Bonni, A

J Neurosci 2004
Participants
Input
Output
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as an event of
Catalyst Activity

JUN kinase activity of p-T,Y-MAPK8 [cytosol]

Physical Entity
p-T,Y-MAPK8 [cytosol] (Homo sapiens)
Activity
JUN kinase activity (GO:0004705)
Orthologous Events
JNK phosphorylates BIM, BAD and other targets (Bos taurus)
JNK phosphorylates BIM, BAD and other targets (Canis familiaris)
JNK phosphorylates BIM, BAD and other targets (Mus musculus)
JNK phosphorylates BIM, BAD and other targets (Rattus norvegicus)
JNK phosphorylates BIM, BAD and other targets (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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