JNK phosphorylates BIM, BAD and other targets

Stable Identifier
R-HSA-205075
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once activated, JNK phosphorylates targets in cytoplasm, including BIM and BAD that promote the release of cytochrome c and activation of caspases 9, 6 and 3.

Literature References
PubMed ID Title Journal Year
15470142 Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis

Becker, EB, Howell, J, Kodama, Y, Barker, PA, Bonni, A

J Neurosci 2004
14673001 Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad

Bhakar, AL, Howell, JL, Paul, CE, Salehi, AH, Becker, EB, Said, F, Bonni, A, Barker, PA

J Neurosci 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
JUN kinase activity of p-T,Y-MAPK8 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created