JNK phosphorylates BIM, BAD and other targets

Stable Identifier
R-HSA-205075
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Once activated, JNK phosphorylates targets in cytoplasm, including BIM and BAD that promote the release of cytochrome c and activation of caspases 9, 6 and 3.
Literature References
PubMed ID Title Journal Year
14673001 Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad

Becker, EB, Bonni, A, Said, F, Bhakar, AL, Salehi, AH, Howell, JL, Barker, PA, Paul, CE

J Neurosci 2003
15470142 Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis

Howell, J, Kodama, Y, Becker, EB, Bonni, A, Barker, PA

J Neurosci 2004
Participants
Participates
Catalyst Activity

JUN kinase activity of p-T,Y-MAPK8 [cytosol]

Orthologous Events
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