Reactome | B4GALTs transfer Gal to a branch of keratan

B4GALTs transfer Gal to a branch of keratan

Stable Identifier

R-HSA-2046298

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

B4GALTs can add galactose to a branch of an N-glycan to extend a keratan chain

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

B4GALTs transfer Gal to a branch of keratan

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The family of beta 4-galactosyltransferases (B4GALTs) is composed by at least six known members with different Km and acceptor specificities (Guo et al. 2001) that probably originated by gene duplication (Lo et al. 1998). They mediate the transfer of galactose to N-glycan structures, in this case, to elongate an antenna with a keratan chain. B4GALT1 is associated with Congenital Disorder of Glycosylation of type IId (MIM:607091) (Hansske et al. 2002), and is expressed as two splicing isoforms of which only one is localized in the Golgi system (Lopez et al. 1991, Schaub et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
17021253	Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated Rohrer, J, Berger, B, Berger, EG, Schaub, BE	Mol Biol Cell	2006
11901181	Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId Hoffmann, GF, Lübke, T, Peters, V, Hansske, B, Körner, C, Heidemann, PH, von Figura, K, Berger, EG, Höning, S, Thiel, C, Hasilik, M	J Clin Invest	2002
11588157	Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells Guo, S, Sato, T, Furukawa, K, Shirane, K	Glycobiology	2001
9597550	The expanding beta 4-galactosyltransferase gene family: messages from the databanks Pevsner, J, Shaper, NL, Shaper, JH, Lo, NW	Glycobiology	1998
1714903	Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase Shur, BD, Lopez, LC, Youakim, A, Evans, SC	J Biol Chem	1991