Reactome | Translocation of tetracosapentaenoyl-CoA to peroxisomes

Translocation of tetracosapentaenoyl-CoA to peroxisomes

Stable Identifier

R-HSA-2046093

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen, peroxisomal membrane, peroxisomal matrix

ReviewStatus

5/5

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Translocation of tetracosapentaenoyl-CoA to peroxisomes

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Prior to this reaction all the enzymes involved in the desaturation and elongation of linoleic acid are located in the ER, but for this last step tetracosapentaenoyl-CoA must be transferred to the peroxisomes for partial beta-oxidation to docosapentaenoyl-CoA (DPA-CoA, 4,7,10,13,16-22:5(n-6)) (Su et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
9684854	Analysis of the putative role of 24-carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids Infante, JP, Huszagh, VA	FEBS Lett	1998
12897190	Studies on the metabolic fate of n-3 polyunsaturated fatty acids Ferdinandusse, S, Denis, S, Dacremont, G, Wanders, RJA	J Lipid Res	2003
11500517	Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis Su, HM, Moser, AB, Moser, HW, Watkins, PA	J Biol Chem	2001