Reactome | Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA

Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA

Stable Identifier

R-HSA-2046084

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

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Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA

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Alpha-linoloyl-CoA is converted to Stearidonoyl-CoA (SDA, 6,9,12,15-18:3(n-3)) by delta-6-destaurase (fatty acid desaturase-2, FADS2). FADS2 uses the cytochrome b5 system to add a double bond at position 6. This is the rate limiting step in alpha-linolenic acid (ALA) metabolism (Horrobin 1993).

Literature References

PubMed ID	Title	Journal	Year
1346092	Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats Yamazaki, K, Fujikawa, M, Hamazaki, T, Yano, S, Shono, T	Biochim Biophys Acta	1992
19056654	Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits Whelan, J	J Nutr	2009
12562861	Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element Tang, C, Cho, HP, Nakamura, MT, Clarke, SD	J Lipid Res	2003
12713571	Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity Ge, L, Gordon, JS, Hsuan, C, Stenn, K, Prouty, SM	J Invest Dermatol	2003
11988075	The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis d'Andréa, S, Guillou, H, Jan, S, Catheline, D, Thibault, JN, Bouriel, M, Rioux, V, Legrand, P	Biochem J	2002