Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA

Stable Identifier
R-HSA-2046084
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Alpha-linoloyl-CoA is converted to Stearidonoyl-CoA (SDA, 6,9,12,15-18:3(n-3)) by delta-6-destaurase (fatty acid desaturase-2, FADS2). FADS2 uses the cytochrome b5 system to add a double bond at position 6. This is the rate limiting step in alpha-linolenic acid (ALA) metabolism (Horrobin 1993).

Literature References
PubMed ID Title Journal Year
1346092 Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats

Yamazaki, K, Fujikawa, M, Hamazaki, T, Yano, S, Shono, T

Biochim Biophys Acta 1992
19056654 Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits

Whelan, J

J Nutr 2009
12562861 Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element

Tang, C, Cho, HP, Nakamura, MT, Clarke, SD

J Lipid Res 2003
12713571 Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity

Ge, L, Gordon, JS, Hsuan, C, Stenn, K, Prouty, SM

J Invest Dermatol 2003
11988075 The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis

d'Andréa, S, Guillou, H, Jan, S, Catheline, D, Thibault, JN, Bouriel, M, Rioux, V, Legrand, P

Biochem J 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
linoleoyl-CoA desaturase activity of FADS2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created