Alpha-linoloyl-CoA is converted to Stearidonoyl-CoA (SDA, 6,9,12,15-18:3(n-3)) by delta-6-destaurase (fatty acid desaturase-2, FADS2). FADS2 uses the cytochrome b5 system to add a double bond at position 6. This is the rate limiting step in alpha-linolenic acid (ALA) metabolism (Horrobin 1993).
Yamazaki, K, Fujikawa, M, Hamazaki, T, Yano, S, Shono, T
Whelan, J
Tang, C, Cho, HP, Nakamura, MT, Clarke, SD
Ge, L, Gordon, JS, Hsuan, C, Stenn, K, Prouty, SM
d'Andréa, S, Guillou, H, Jan, S, Catheline, D, Thibault, JN, Bouriel, M, Rioux, V, Legrand, P
linoleoyl-CoA desaturase activity of FADS2 [endoplasmic reticulum membrane]
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