Alpha-linoloyl-CoA is converted to Stearidonoyl-CoA (SDA, 6,9,12,15-18:3(n-3)) by delta-6-destaurase (fatty acid desaturase-2, FADS2). FADS2 uses the cytochrome b5 system to add a double bond at position 6. This is the rate limiting step in alpha-linolenic acid (ALA) metabolism (Horrobin 1993).
Whelan, J
Yano, S, Shono, T, Hamazaki, T, Yamazaki, K, Fujikawa, M
Nakamura, MT, Cho, HP, Tang, C, Clarke, SD
Prouty, SM, Gordon, JS, Ge, L, Hsuan, C, Stenn, K
Jan, S, d'Andréa, S, Catheline, D, Bouriel, M, Thibault, JN, Legrand, P, Rioux, V, Guillou, H
linoleoyl-CoA desaturase activity of FADS2 [endoplasmic reticulum membrane]
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