Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA

Stable Identifier
Reaction [transition]
Homo sapiens
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Alpha-linoloyl-CoA is converted to Stearidonoyl-CoA (SDA, 6,9,12,15-18:3(n-3)) by delta-6-destaurase (fatty acid desaturase-2, FADS2). FADS2 uses the cytochrome b5 system to add a double bond at position 6. This is the rate limiting step in alpha-linolenic acid (ALA) metabolism (Horrobin 1993).
Literature References
PubMed ID Title Journal Year
19056654 Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits

Whelan, J

J Nutr 2009
1346092 Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats

Yano, S, Shono, T, Hamazaki, T, Yamazaki, K, Fujikawa, M

Biochim Biophys Acta 1992
12562861 Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element

Nakamura, MT, Cho, HP, Tang, C, Clarke, SD

J Lipid Res 2003
12713571 Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity

Prouty, SM, Gordon, JS, Ge, L, Hsuan, C, Stenn, K

J Invest Dermatol 2003
11988075 The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis

Jan, S, d'Andréa, S, Catheline, D, Bouriel, M, Thibault, JN, Legrand, P, Rioux, V, Guillou, H

Biochem J 2002
Catalyst Activity

linoleoyl-CoA desaturase activity of FADS2 [endoplasmic reticulum membrane]

Orthologous Events
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