SEC31:SEC13 and v-SNARE recruitment

Stable Identifier
Reaction [binding]
Homo sapiens
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The outer coat proteins SEC13 and SEC31A are thought to exist in a cytosolic heterohexamer with SEC23IP and are recruited to the ER through interaction with pre-bound SEC23-SEC24 complexes (Stephens et al, 2000; Hammond and Glick, 2000; Ong et al, 2010; reviewed in Szul and Sztul, 2011). v-SNAREs such as the SEC22 proteins are also incorporated into the emerging vesicle through interactions with components of the COPII coat (Xu et al, 2000; Mancias and Goldberg, 2008; Gordon et al, 2010; reviewed in Szul and Sztul, 2011; Lord et al, 2013).

Literature References
PubMed ID Title Journal Year
22013193 COPII and COPI traffic at the ER-Golgi interface

Sztul, E, Szul, T

Physiology (Bethesda) 2011
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R

J Cell Sci 2000
11035026 Subunit structure of a mammalian ER/Golgi SNARE complex

Xu, D, Joglekar, AP, Williams, AL, Hay, JC

J. Biol. Chem. 2000
23378591 The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi

Ferro-Novick, S, Miller, EA, Lord, C

Cold Spring Harb Perspect Biol 2013
20679433 p125A exists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport

Hong, W, Loo, LS, Ong, YS, Tang, BL

J. Cell Biol. 2010
20545907 A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells

Gordon, DE, Bond, LM, Sahlender, DA, Peden, AA

Traffic 2010
10982397 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells

Glick, BS, Hammond, AT

Mol Biol Cell 2000
18843296 Structural basis of cargo membrane protein discrimination by the human COPII coat machinery

Goldberg, J, Mancias, JD

EMBO J. 2008
Orthologous Events
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