Reactome | SEC31:SEC13 and v-SNARE recruitment

SEC31:SEC13 and v-SNARE recruitment

Stable Identifier

R-HSA-204008

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)

General

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The outer coat proteins SEC13 and SEC31A are thought to exist in a cytosolic heterohexamer with SEC23IP and are recruited to the ER through interaction with pre-bound SEC23-SEC24 complexes (Stephens et al, 2000; Hammond and Glick, 2000; Ong et al, 2010; reviewed in Szul and Sztul, 2011). v-SNAREs such as the SEC22 proteins are also incorporated into the emerging vesicle through interactions with components of the COPII coat (Xu et al, 2000; Mancias and Goldberg, 2008; Gordon et al, 2010; reviewed in Szul and Sztul, 2011; Lord et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
10825291	COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites Stephens, DJ, Lin-Marq, N, Pagano, A, Pepperkok, R, Paccaud, JP	J Cell Sci	2000
22013193	COPII and COPI traffic at the ER-Golgi interface Szul, T, Sztul, E	Physiology (Bethesda)	2011
11035026	Subunit structure of a mammalian ER/Golgi SNARE complex Xu, D, Joglekar, AP, Williams, AL, Hay, JC	J. Biol. Chem.	2000
23378591	The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi Lord, C, Ferro-Novick, S, Miller, EA	Cold Spring Harb Perspect Biol	2013
20679433	p125A exists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport Ong, YS, Tang, BL, Loo, LS, Hong, W	J. Cell Biol.	2010
20545907	A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells Gordon, DE, Bond, LM, Sahlender, DA, Peden, AA	Traffic	2010
10982397	Dynamics of transitional endoplasmic reticulum sites in vertebrate cells Hammond, AT, Glick, BS	Mol Biol Cell	2000
18843296	Structural basis of cargo membrane protein discrimination by the human COPII coat machinery Mancias, JD, Goldberg, J	EMBO J.	2008