Translocation of YAP1 to the nucleus

Stable Identifier
R-HSA-2032770
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Translocation of YAP1 to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In its unphosphorylated state, the YAP1 transcriptional coactivator moves freely into the nucleus. Phosphorylated YAP1, in contrast, is sequestered in the cytosol (Hao et al. 2008).

Literature References
PubMed ID Title Journal Year
18158288 Tumor suppressor LATS1 is a negative regulator of oncogene YAP

Cheung, K, Rashidi, B, Yang, X, Hao, Y, Chun, A

J Biol Chem 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
Translocation of YAP1 to the nucleus (Bos taurus)
Translocation of YAP1 to the nucleus (Caenorhabditis elegans)
Translocation of YAP1 to the nucleus (Danio rerio)
Translocation of YAP1 to the nucleus (Drosophila melanogaster)
Translocation of YAP1 to the nucleus (Gallus gallus)
Translocation of YAP1 to the nucleus (Mus musculus)
Translocation of YAP1 to the nucleus (Rattus norvegicus)
Translocation of YAP1 to the nucleus (Sus scrofa)
Translocation of YAP1 to the nucleus (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-07)
Cite Us!