Reactome | OLR1 binds to oxidized LDL

OLR1 binds to oxidized LDL

Stable Identifier

R-HSA-203130

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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The lectin-like oxidized low density lipoprotein receptor- 1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis.

Literature References

PubMed ID	Title	Journal	Year
9693095	Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor Yoshida, H, Green, S, Kondratenko, N, Steinberg, D, Quehenberger, O	Biochem J	1998
15000751	Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells Tokuyasu, K, Ogawa, S, Xie, Q, Machida, S, Matsunaga, S, Niimi, S, Sakakibara, Y	DNA Cell Biol	2004
9763524	Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein Hoshikawa, H, Ochi, H, Sawamura, T, Aoyama, T, Kume, N, Masaki, T, Kita, T, Nishi, E, Moriwaki, H	Arterioscler Thromb Vasc Biol	1998
9052782	An endothelial receptor for oxidized low-density lipoprotein Tanaka, T, Hoshikawa, H, Miwa, S, Aiba, Y, Sawamura, T, Kume, N, Katsura, Y, Masaki, T, Kita, T, Aoyama, T, Moriwaki, H	Nature	1997
11256994	Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor Shi, X, Machida, S, Niimi, S, Ohtani, T	J Cell Sci	2001