OLR1 binds to oxidized LDL

Stable Identifier
R-HSA-203130
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The lectin-like oxidized low density lipoprotein receptor- 1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis.

Literature References
PubMed ID Title Journal Year
15000751 Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells

Xie, Q, Matsunaga, S, Niimi, S, Ogawa, S, Tokuyasu, K, Sakakibara, Y, Machida, S

DNA Cell Biol 2004
9693095 Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor

Yoshida, H, Kondratenko, N, Green, S, Steinberg, D, Quehenberger, O

Biochem J 1998
9763524 Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein

Moriwaki, H, Kume, N, Sawamura, T, Aoyama, T, Hoshikawa, H, Ochi, H, Nishi, E, Masaki, T, Kita, T

Arterioscler Thromb Vasc Biol 1998
9052782 An endothelial receptor for oxidized low-density lipoprotein

Sawamura, T, Kume, N, Aoyama, T, Moriwaki, H, Hoshikawa, H, Aiba, Y, Tanaka, T, Miwa, S, Katsura, Y, Kita, T, Masaki, T

Nature 1997
11256994 Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor

Shi, X, Niimi, S, Ohtani, T, Machida, S

J Cell Sci 2001
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