Reactome | OLR1 binds to oxidized LDL

OLR1 binds to oxidized LDL

Stable Identifier

R-HSA-203130

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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The lectin-like oxidized low density lipoprotein receptor- 1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis.

Literature References

PubMed ID	Title	Journal	Year
9693095	Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor Yoshida, H, Kondratenko, N, Green, S, Steinberg, D, Quehenberger, O	Biochem J	1998
15000751	Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells Xie, Q, Matsunaga, S, Niimi, S, Ogawa, S, Tokuyasu, K, Sakakibara, Y, Machida, S	DNA Cell Biol	2004
9763524	Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein Moriwaki, H, Kume, N, Sawamura, T, Aoyama, T, Hoshikawa, H, Ochi, H, Nishi, E, Masaki, T, Kita, T	Arterioscler Thromb Vasc Biol	1998
9052782	An endothelial receptor for oxidized low-density lipoprotein Sawamura, T, Kume, N, Aoyama, T, Moriwaki, H, Hoshikawa, H, Aiba, Y, Tanaka, T, Miwa, S, Katsura, Y, Kita, T, Masaki, T	Nature	1997
11256994	Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor Shi, X, Niimi, S, Ohtani, T, Machida, S	J Cell Sci	2001