Reactome | Hydrolysis of PC to PA by PLD

Hydrolysis of PC to PA by PLD

Stable Identifier

R-HSA-2029471

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Phospholipase D (PLD) catalyses the hydrolysis of the membrane phospholipid, phosphatidylcholine (PC) to generate choline and metabolically active phosphatidic acid (PA) (Lennartz 1999). Pharmacological inhibition studies show that PLD participates in FCGR-mediated phagocytosis (Kusner et al. 1996). There is an increase in the activity of PLD following the activation of phagocytosis via FCGR (Kusner et al. 1999). Following activation of FCGR, PLD translocates to the plasma membrane at the phagocytic cup and generate PA. This PA can be converted to DAG through the action of phosphatidic acid phosphatase-1 (PAP-1). Thus activation of PLD may be an additional pathway leading to PKC activation.
The two isoforms PLD1 and PLD2 are both shown to be essential for the formation of phagosome at different stages. PLD1 is localized on the endosomal/lysosomal compartment and PLD2 is localized at the plasma membrane. PLD2 may be linked to phagosome formation whereas PLD1 may be involved in the focal exocytosis at the plasma membrane and also in the maturation process (Carrotte et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16497229	Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis Corrotte, M, Chasserot-Golaz, S, Huang, P, Du, G, Ktistakis, NT, Frohman, MA, Vitale, N, Bader, MF, Grant, NJ	Traffic	2006
9973503	Fc gamma receptor-mediated activation of phospholipase D regulates macrophage phagocytosis of IgG-opsonized particles Kusner, DJ, Hall, CF, Jackson, S	J Immunol	1999
15294978	Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis Iyer, SS, Barton, JA, Bourgoin, S, Kusner, DJ	J Immunol	2004