Hydrolysis of PC to PA by PLD

Stable Identifier
R-HSA-2029471
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phospholipase D (PLD) catalyses the hydrolysis of the membrane phospholipid, phosphatidylcholine (PC) to generate choline and metabolically active phosphatidic acid (PA) (Lennartz 1999). Pharmacological inhibition studies show that PLD participates in FCGR-mediated phagocytosis (Kusner et al. 1996). There is an increase in the activity of PLD following the activation of phagocytosis via FCGR (Kusner et al. 1999). Following activation of FCGR, PLD translocates to the plasma membrane at the phagocytic cup and generate PA. This PA can be converted to DAG through the action of phosphatidic acid phosphatase-1 (PAP-1). Thus activation of PLD may be an additional pathway leading to PKC activation.
The two isoforms PLD1 and PLD2 are both shown to be essential for the formation of phagosome at different stages. PLD1 is localized on the endosomal/lysosomal compartment and PLD2 is localized at the plasma membrane. PLD2 may be linked to phagosome formation whereas PLD1 may be involved in the focal exocytosis at the plasma membrane and also in the maturation process (Carrotte et al. 2006).

Literature References
PubMed ID Title Journal Year
9973503 Fc gamma receptor-mediated activation of phospholipase D regulates macrophage phagocytosis of IgG-opsonized particles

Kusner, DJ, Hall, CF, Jackson, S

J Immunol 1999
16497229 Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis

Corrotte, M, Chasserot-Golaz, S, Huang, P, Du, G, Ktistakis, NT, Frohman, MA, Vitale, N, Bader, MF, Grant, NJ

Traffic 2006
15294978 Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis

Iyer, SS, Barton, JA, Bourgoin, S, Kusner, DJ

J Immunol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipase D activity of PLD [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created