Caspase-mediated cleavage of E-Cadherin

Stable Identifier
R-HSA-202939
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The cleavage of E-cadherin at both the intracellular and extracellular domains likely contributes to the disruption of cadherin-mediated cell-cell contacts in apoptotic cells. Loss of cell contact is necessary for cell rounding and exit from the epithelium (Steinhusen et al., 2001).
Literature References
PubMed ID Title Journal Year
11076937 Cleavage and shedding of E-cadherin after induction of apoptosis

Huber, O, Bommert, K, Steinhusen, U, Badock, V, Tauber, R, Weiske, J

J. Biol. Chem. 2001
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Orthologous Events
Authored
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Created
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