Reactome | Recruitment of PLCgamma to membrane

Recruitment of PLCgamma to membrane

Stable Identifier

R-HSA-2029270

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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PLCgamma (PLCG) is recruited to FCGR and the phosphorylated Y342 and Y346 in SYK have been reported to be involved in the interaction of PLCG (Law et al. 1996). PLCG accumulates at the phagocytic cup during FCGR, but the exact role of PLCG in the regulation of phagocytosis is not clear. It may be involved in FCGR signaling by activating PKC through DAG production (Garcia-Garcia & Rosales 2002 )

Literature References

PubMed ID	Title	Journal	Year
7517665	Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils Dusi, S, Donini, M, Della Bianca, V, Rossi, F	Biochem Biophys Res Commun	1994
8657103	Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk Chandran, KA, Law, CL, Clark, EA, Sidorenko, SP	Mol Cell Biol	1996