AMOT proteins bind YAP1

Stable Identifier
R-HSA-2028724
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AMOT proteins bind YAP1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AMOT (130 KDa isoform), AMOTL1, and AMOTL2 can each bind YAP1 and sequester it in the cytosol. This interaction is not dependent on YAP1 phosphorylation and may thus be a means of negatively regulating YAP activity in addition to the ones dependent on Hippo pathway-dependent phosphorylation. AMOT - YAP1 binding is dependent on sequence motifs in the amino terminal portions of the AMOT proteins (and that are absent from the AMOT 80 KDa isoform, which does not bind YAP1) (Wang et al. 2010; Chan et al. 2011).

Literature References
PubMed ID Title Journal Year
21224387 Hippo pathway-independent restriction of TAZ and YAP by angiomotin

Chan, SW, Lim, CJ, Chong, YF, Pobbati, AV, Huang, C, Hong, W

J Biol Chem 2011
21187284 Angiomotin-like proteins associate with and negatively regulate YAP1

Wang, W, Huang, J, Chen, J

J Biol Chem 2011
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
AMOT proteins bind YAP1 (Bos taurus)
AMOT proteins bind YAP1 (Danio rerio)
AMOT proteins bind YAP1 (Gallus gallus)
AMOT proteins bind YAP1 (Mus musculus)
AMOT proteins bind YAP1 (Rattus norvegicus)
AMOT proteins bind YAP1 (Sus scrofa)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-04)
Cite Us!