AMOT proteins bind YAP1

Stable Identifier
R-HSA-2028724
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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AMOT proteins bind YAP1
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AMOT (130 KDa isoform), AMOTL1, and AMOTL2 can each bind YAP1 and sequester it in the cytosol. This interaction is not dependent on YAP1 phosphorylation and may thus be a means of negatively regulating YAP activity in addition to the ones dependent on Hippo pathway-dependent phosphorylation. AMOT - YAP1 binding is dependent on sequence motifs in the amino terminal portions of the AMOT proteins (and that are absent from the AMOT 80 KDa isoform, which does not bind YAP1) (Wang et al. 2010; Chan et al. 2011).

Literature References
PubMed ID Title Journal Year
21187284 Angiomotin-like proteins associate with and negatively regulate YAP1

Wang, W, Chen, J, Huang, J

J Biol Chem 2011
21224387 Hippo pathway-independent restriction of TAZ and YAP by angiomotin

Pobbati, AV, Lim, CJ, Hong, W, Huang, C, Chan, SW, Chong, YF

J Biol Chem 2011
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Orthologous Events
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AMOT proteins bind YAP1 (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-04)
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