Reactome | YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1

YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1

Stable Identifier

R-HSA-2028644

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1

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YWHAB (14-3-3 beta/alpha) binds phosphorylated YAP1 proteins, sequestering them in the cytosol. Structural studies indicate that the active form of YWHAB (14-3-3 beta/alpha) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with YAP1 is unknown and has been annotated arbitrarily here to involve one YAP1 molecule and a YWHAB (14-3-3 beta/alpha) dimer. While YAP1 can be phosphorylated on several serine residues, phosphorylation of serine-127 appears to be critical for YWHAB(14-3-3 beta/alpha) binding (Zhao et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17085597	Structural basis for protein-protein interactions in the 14-3-3 protein family Elkins, JM, Sobott, F, Papagrigoriou, E, Grossmann, JG, Robinson, CV, Sundström, M, Lee, WH, Yang, X, Doyle, DA	Proc Natl Acad Sci U S A	2006
17974916	Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Zheng, P, Halder, G, Ye, K, Lai, ZC, Yu, J, Wei, X, Guan, KL, Chinnaiyan, A, Xie, J, Yang, Q, Li, L, Kim, J, Li, W, Ikenoue, T, Udan, RS, Zhao, B	Genes Dev	2007