YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1

Stable Identifier
R-HSA-2028644
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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YWHAB (14-3-3 beta/alpha) binds phosphorylated YAP1 proteins, sequestering them in the cytosol. Structural studies indicate that the active form of YWHAB (14-3-3 beta/alpha) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with YAP1 is unknown and has been annotated arbitrarily here to involve one YAP1 molecule and a YWHAB (14-3-3 beta/alpha) dimer. While YAP1 can be phosphorylated on several serine residues, phosphorylation of serine-127 appears to be critical for YWHAB(14-3-3 beta/alpha) binding (Zhao et al. 2007).

Literature References
PubMed ID Title Journal Year
17974916 Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B, Wei, X, Li, W, Udan, RS, Yang, Q, Kim, J, Xie, J, Ikenoue, T, Yu, J, Li, L, Zheng, P, Ye, K, Chinnaiyan, A, Halder, G, Lai, ZC, Guan, KL

Genes Dev 2007
17085597 Structural basis for protein-protein interactions in the 14-3-3 protein family

Yang, X, Lee, WH, Sobott, F, Papagrigoriou, E, Robinson, CV, Grossmann, JG, Sundström, M, Doyle, DA, Elkins, JM

Proc Natl Acad Sci U S A 2006
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