Phosphorylation of MOB1A and B by p-STK3 (p-MST2)

Stable Identifier
R-HSA-2028635
Type
Reaction
Species
Homo sapiens
Compartment
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Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK3 (p-MST2). Phosphorylated (active) STK3 (p-MST2) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Threonine residues 12 and 35 have been experimentally identifed as the targets of MOB1A phosphorylation; the homologous residues of MOB1B are inferred likewise to be targets (Praskova et al. 2008).

Literature References
PubMed ID Title Journal Year
18328708 MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

Xia, F, Praskova, M, Avruch, J

Curr Biol 2008
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-STK3:p-SAV1 [cytosol]

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