Reactome | Integrin alphaMbeta2 (MAC1) binds JAM3

Integrin alphaMbeta2 (MAC1) binds JAM3

Stable Identifier

R-HSA-202727

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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Recruitment of monocytic cells to the vessel wall by platelets is mediated via CD11b/CD18 (Mac-1) and platelet JAM-C. In the case of dendritic cells, this interaction leads to their activation and platelet phagocytosis. This process may be of importance for progression of atherosclerotic lesions.

Literature References

PubMed ID	Title	Journal	Year
17525755	The role of junctional adhesion molecules in vascular inflammation Weber, C, Fraemohs, L, Dejana, E	Nat Rev Immunol	2007
17379836	Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro Langer, HF, Daub, K, Braun, G, Schonberger, T, May, AE, Schaller, M, Stein, GM, Stellos, K, Bueltmann, A, Siegel-Axel, D, Wendel, HP, Aebert, H, Roecken, M, Seizer, P, Santoso, S, Wesselborg, S, Brossart, P, Gawaz, M	Arterioscler Thromb Vasc Biol	2007