Integrin alphaMbeta2 (MAC1) binds JAM3

Stable Identifier
Reaction [binding]
Homo sapiens
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Recruitment of monocytic cells to the vessel wall by platelets is mediated via CD11b/CD18 (Mac-1) and platelet JAM-C. In the case of dendritic cells, this interaction leads to their activation and platelet phagocytosis. This process may be of importance for progression of atherosclerotic lesions.

Literature References
PubMed ID Title Journal Year
17525755 The role of junctional adhesion molecules in vascular inflammation

Weber, C, Fraemohs, L, Dejana, E

Nat Rev Immunol 2007
17379836 Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro

Langer, HF, Daub, K, Braun, G, Schonberger, T, May, AE, Schaller, M, Stein, GM, Stellos, K, Bueltmann, A, Siegel-Axel, D, Wendel, HP, Aebert, H, Roecken, M, Seizer, P, Santoso, S, Wesselborg, S, Brossart, P, Gawaz, M

Arterioscler Thromb Vasc Biol 2007
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