F11R dimerises

Stable Identifier
R-HSA-202726
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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F11R (JAM-A) is the most widely expressed member of the family, and has been shown to be expressed on endothelial and epithelial cells, on platelets, and on a number of leukocyte subsets. In endothelial cells, F11R locates to the tight junctions, where it appears to engage in homophilic binding to F11R on adjacent cells, an interaction that is considered to play a critical role in angiogenesis.

Literature References
PubMed ID Title Journal Year
16783819 Junctional adhesion molecule-A regulates cell migration and resistance to shear stress

Huang, H, Cruz, F, Bazzoni, G

J Cell Physiol 2006
17615384 JAM family and related proteins in leukocyte migration (Vestweber series)

Bradfield, PF, Nourshargh, S, Aurrand-Lions, M, Imhof, BA

Arterioscler Thromb Vasc Biol 2007
17525755 The role of junctional adhesion molecules in vascular inflammation

Weber, C, Fraemohs, L, Dejana, E

Nat Rev Immunol 2007
17505016 JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration

Woodfin, A, Reichel, CA, Khandoga, A, Corada, M, Voisin, MB, Scheiermann, C, Haskard, DO, Dejana, E, Krombach, F, Nourshargh, S

Blood 2007
Participants
Participant Of
Orthologous Events
Authored
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Created