Reactome | F11R dimerises

F11R dimerises

Stable Identifier

R-HSA-202726

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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F11R (JAM-A) is the most widely expressed member of the family, and has been shown to be expressed on endothelial and epithelial cells, on platelets, and on a number of leukocyte subsets. In endothelial cells, F11R locates to the tight junctions, where it appears to engage in homophilic binding to F11R on adjacent cells, an interaction that is considered to play a critical role in angiogenesis.

Literature References

PubMed ID	Title	Journal	Year
17615384	JAM family and related proteins in leukocyte migration (Vestweber series) Bradfield, PF, Nourshargh, S, Aurrand-Lions, M, Imhof, BA	Arterioscler Thromb Vasc Biol	2007
16783819	Junctional adhesion molecule-A regulates cell migration and resistance to shear stress Huang, H, Cruz, F, Bazzoni, G	J Cell Physiol	2006
17525755	The role of junctional adhesion molecules in vascular inflammation Weber, C, Fraemohs, L, Dejana, E	Nat Rev Immunol	2007
17505016	JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration Woodfin, A, Reichel, CA, Khandoga, A, Corada, M, Voisin, MB, Scheiermann, C, Haskard, DO, Dejana, E, Krombach, F, Nourshargh, S	Blood	2007