PSGL-1 is expressed as a homodimer of two 120-kDa subunits that binds all four selectins, with the highest affinity for P-selectin, and is known to be constitutively expressed on the surface of platelets and most types of leukocytes. Besides playing a critical role in the inflammatory response by mediating leukocyte-leukocyte and leukocyte-endothelium interactions, PSGL-1 also participates in the hemostatic process by mediating leukocyte-platelet interactions.
Lyons, DE, Cummings, RD, Lichenstein, HS, Moore, KL, Eaton, SF, McEver, RP
Horrevoets, AJ, Zwaginga, JJ, Hordijk, PL, Beckers, C, Fernandez-Borja, M, van Thienen, JV, van Gils, JM, Garcia-Vallejo, JJ, da Costa Martins, P
Ulfman, LH, Zwaginga, JJ, Hordijk, PL, van den Berk, N, Koenderman, L, da Costa Martins, P
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