P-selectin binds P-selectin ligand

Stable Identifier
R-HSA-202724
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PSGL-1 is expressed as a homodimer of two 120-kDa subunits that binds all four selectins, with the highest affinity for P-selectin, and is known to be constitutively expressed on the surface of platelets and most types of leukocytes. Besides playing a critical role in the inflammatory response by mediating leukocyte-leukocyte and leukocyte-endothelium interactions, PSGL-1 also participates in the hemostatic process by mediating leukocyte-platelet interactions.

Literature References
PubMed ID Title Journal Year
17322099 P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium

da Costa Martins, P, Garcia-Vallejo, JJ, van Thienen, JV, Fernandez-Borja, M, van Gils, JM, Beckers, C, Horrevoets, AJ, Hordijk, PL, Zwaginga, JJ

Arterioscler Thromb Vasc Biol 2007
7521878 The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine

Moore, KL, Eaton, SF, Lyons, DE, Lichenstein, HS, Cummings, RD, McEver, RP

J. Biol. Chem. 1994
14615387 Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation

da Costa Martins, P, van den Berk, N, Ulfman, LH, Koenderman, L, Hordijk, PL, Zwaginga, JJ

Arterioscler Thromb Vasc Biol 2004
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