Reactome | P-selectin binds P-selectin ligand

P-selectin binds P-selectin ligand

Stable Identifier

R-HSA-202724

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PSGL-1 is expressed as a homodimer of two 120-kDa subunits that binds all four selectins, with the highest affinity for P-selectin, and is known to be constitutively expressed on the surface of platelets and most types of leukocytes. Besides playing a critical role in the inflammatory response by mediating leukocyte-leukocyte and leukocyte-endothelium interactions, PSGL-1 also participates in the hemostatic process by mediating leukocyte-platelet interactions.

Literature References

PubMed ID	Title	Journal	Year
7521878	The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine Moore, KL, Eaton, SF, Lyons, DE, Lichenstein, HS, Cummings, RD, McEver, RP	J. Biol. Chem.	1994
17322099	P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium da Costa Martins, P, Garcia-Vallejo, JJ, van Thienen, JV, Fernandez-Borja, M, van Gils, JM, Beckers, C, Horrevoets, AJ, Hordijk, PL, Zwaginga, JJ	Arterioscler Thromb Vasc Biol	2007
14615387	Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation da Costa Martins, P, van den Berk, N, Ulfman, LH, Koenderman, L, Hordijk, PL, Zwaginga, JJ	Arterioscler Thromb Vasc Biol	2004