PSGL-1 is expressed as a homodimer of two 120-kDa subunits that binds all four selectins, with the highest affinity for P-selectin, and is known to be constitutively expressed on the surface of platelets and most types of leukocytes. Besides playing a critical role in the inflammatory response by mediating leukocyte-leukocyte and leukocyte-endothelium interactions, PSGL-1 also participates in the hemostatic process by mediating leukocyte-platelet interactions.
da Costa Martins, P, Garcia-Vallejo, JJ, van Thienen, JV, Fernandez-Borja, M, van Gils, JM, Beckers, C, Horrevoets, AJ, Hordijk, PL, Zwaginga, JJ
Moore, KL, Eaton, SF, Lyons, DE, Lichenstein, HS, Cummings, RD, McEver, RP
da Costa Martins, P, van den Berk, N, Ulfman, LH, Koenderman, L, Hordijk, PL, Zwaginga, JJ
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