During the phosphorylation of the IKK beta, the regulatory subunit NEMO undergoes K-63-linked polyubiquitination. Ubiquitinated TRAF6 trimer, acts as a E3 ligase and induces this ubiquitination. The ubiquitin target sites in NEMO are not yet clearly identified. Studies of different NF-kB signaling pathways revealed several potential ubiquitination sites on NEMO (e.g., K285, K277, K309 and K399) (Fuminori et al. 2009).
Sebban-Benin, H, Pescatore, A, Courtois, G, Fusco, F, Ursini, MV, Yamaoka, S, Gautheron, J, Pascuale, V, Moncla, A
Karin, M, Hacker, H
ubiquitin-protein transferase activity of Ub-TRAF6 trimer bound to CBM complex [plasma membrane]
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