Ubiquitination of NEMO by TRAF6

Stable Identifier
R-HSA-202534
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
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Ubiquitination of NEMO by TRAF6
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During the phosphorylation of the IKK beta, the regulatory subunit NEMO undergoes K-63-linked polyubiquitination. Ubiquitinated TRAF6 trimer, acts as a E3 ligase and induces this ubiquitination. The ubiquitin target sites in NEMO are not yet clearly identified. Studies of different NF-kB signaling pathways revealed several potential ubiquitination sites on NEMO (e.g., K285, K277, K309 and K399) (Fuminori et al. 2009).

Literature References
PubMed ID Title Journal Year
17047224 Regulation and function of IKK and IKK-related kinases

Hacker, H, Karin, M

Sci STKE 2006
17728323 Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti

Sebban-Benin, H, Pescatore, A, Fusco, F, Pascuale, V, Gautheron, J, Yamaoka, S, Moncla, A, Ursini, MV, Courtois, G

Hum Mol Genet 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of Ub-TRAF6 trimer bound to CBM complex [plasma membrane]
Physical Entity
Ub-TRAF6 trimer bound to CBM complex [plasma membrane]
Activity
ubiquitin-protein transferase activity (0004842)
Orthologous Events
Ubiquitination of NEMO by TRAF6 (Bos taurus)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Danio rerio)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Xenopus tropicalis)
Authored
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Garapati, P V  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-11-01)