Interaction and oligomerization of MALT1 to Bcl10

Stable Identifier
R-HSA-202478
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Oligomerized Bcl10 facilitates the association with MALT1 to form the CBM signalosome. MALT1 possesses one death domain (DD) and 2 immunoglobulin-like domains (Ig-like) in its N-terminal region and a caspase like domain (CLD) in its C-terminal region. The region between amino acids 107 and 119 of Bcl10 bind to the two Ig-like domains of MALT1. After binding to CARMA1 and Bcl10 complex, MALT1 also undergoes oligomerization. Only the oligomerized forms of Bcl10 and MALT1 are capable of activating IKK.

Literature References
PubMed ID Title Journal Year
15125833 The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

Sun, L, Deng, L, Ea, CK, Xia, ZP, Chen, ZJ

Mol Cell 2004
Participants
Participant Of
Orthologous Events
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Created